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超声引导下眶上神经射频热凝术治疗眶上神经痛:一项回顾性研究

Treatment of Supraorbital Neuralgia Using Ultrasound-Guided Radiofrequency Thermocoagulation of the Supraorbital Nerve: A Retrospective Study.

作者信息

Ren Hao, Shen Ying, Luo Fang

机构信息

Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.

出版信息

J Pain Res. 2020 Jan 29;13:251-259. doi: 10.2147/JPR.S228720. eCollection 2020.

Abstract

PURPOSE

There is no standard clinical treatment protocol for supraorbital neuralgia patients who respond poorly to conservative treatment. Radiofrequency thermocoagulation, a neurologically damaging procedure, is a treatment for supraorbital neuralgia. However, assessments of its long-term efficacy are lacking. Thus, this study aimed to evaluate the long-term efficacy and safety of ultrasound-guided radiofrequency thermocoagulation for treating supraorbital neuralgia.

PATIENTS AND METHODS

We retrospectively reviewed our clinical database for supraorbital neuralgia patients who underwent an ultrasound-guided radiofrequency thermocoagulation procedure. Demographic data and baseline characteristics, time of onset, postoperative pain intensity, time of recurrence, subsequent treatment, complications and side effects were collected and analysed. The Kaplan-Meier estimator was used to determine recurrence-free survival.

RESULTS

A total of 53 supraorbital neuralgia patients were included in this study. All patients experienced complete pain relief within one month. The median follow-up time of the 53 patients was 36.0 months (IQR, 12.0-72.0 months). A total of 13 patients experienced pain recurrence, with a median recurrence-free time of 97 months according to the Kaplan-Meier estimator. The cumulative proportion of recurrence-free survival was 96.2% at 12 months, 88.4% at 24 months, 82.7% at 36 months, 70.0% at 48 months, 66.3% at 60 months, and 49.7% at 97 months. All but one patient with recurrent pain underwent a second or third radiofrequency thermocoagulation procedure and achieved complete pain relief. Numbness of supraorbital nerve innervation occurred in all patients. However, the numbness scores gradually decreased over time.

CONCLUSION

Ultrasound-guided radiofrequency thermocoagulation is a safe, effective treatment for supraorbital neuralgia patients who respond poorly to conservative treatments. These patients attained excellent long-term pain relief with a gradual reduction in numbness.

摘要

目的

对于保守治疗效果不佳的眶上神经痛患者,尚无标准的临床治疗方案。射频热凝术作为一种会对神经造成损伤的治疗方法,用于治疗眶上神经痛。然而,目前缺乏对其长期疗效的评估。因此,本研究旨在评估超声引导下射频热凝术治疗眶上神经痛的长期疗效和安全性。

患者与方法

我们回顾性分析了接受超声引导下射频热凝术的眶上神经痛患者的临床数据库。收集并分析了人口统计学数据和基线特征、发病时间、术后疼痛强度、复发时间、后续治疗、并发症和副作用。采用Kaplan-Meier估计量来确定无复发生存率。

结果

本研究共纳入53例眶上神经痛患者。所有患者在1个月内疼痛完全缓解。53例患者的中位随访时间为36.0个月(四分位间距,12.0 - 72.0个月)。共有13例患者出现疼痛复发,根据Kaplan-Meier估计量,无复发的中位时间为97个月。无复发生存的累积比例在12个月时为96.2%,24个月时为88.4%,36个月时为82.7%,48个月时为70.0%,60个月时为66.3%,97个月时为49.7%。除1例复发疼痛患者外,其余患者均接受了第二次或第三次射频热凝术并实现了疼痛完全缓解。所有患者均出现眶上神经支配区域麻木。然而,麻木评分随时间逐渐降低。

结论

超声引导下射频热凝术对于保守治疗效果不佳的眶上神经痛患者是一种安全、有效的治疗方法。这些患者长期疼痛缓解效果良好,且麻木感逐渐减轻。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac0a/6996227/9e33a2184cce/JPR-13-251-g0001.jpg

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