Department of Endocrinology and Metabolic Disease, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey.
Department of Urology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey.
Andrologia. 2020 May;52(4):e13548. doi: 10.1111/and.13548. Epub 2020 Feb 26.
The visceral adiposity index (VAI), which is calculated by using parameters such as body mass index (BMI), waist circumference, triglyceride, and high-density lipoprotein cholesterol, has been reported to be associated with visceral fat distribution and increased cardiometabolic risk. We aimed to investigate the relationship between the VAI and hormone profiles as well as semen analysis in male infertility. This retrospective study included 278 adult men that were admitted to the urology and endocrine outpatient clinics. Patient data were reviewed, and outcomes were recorded. BMI and VAI were calculated and noted separately. BMI was negatively correlated with serum testosterone and testosterone/ estradiol ratio (T/E2) (p < .05 for all). There was no significant relationship between BMI and semen parameters (p > .05 for all). However, there was a significant negative correlation between VAI and semen parameters, total serum testosterone and T/E2 (p < .05 for all). Furthermore, VAI was independently associated with the total motility score. The increase in visceral adiposity that can be demonstrated by VAI may adversely affect male fertility due to its metabolic and hormonal effects. Since infertility occurs as a result of different metabolic conditions, the underlying mechanisms can be better understood from a multidisciplinary perspective.
内脏脂肪指数（VAI）是通过使用身体质量指数（BMI）、腰围、甘油三酯和高密度脂蛋白胆固醇等参数计算得出的，它与内脏脂肪分布和增加的心血管代谢风险有关。我们旨在研究 VAI 与男性不育症中的激素谱和精液分析之间的关系。这项回顾性研究包括 278 名成年男性，他们被收入泌尿科和内分泌门诊。回顾了患者数据并记录了结果。单独计算并记录了 BMI 和 VAI。BMI 与血清睾酮和睾酮/雌二醇比值（T/E2）呈负相关（p<0.05 均）。BMI 与精液参数无显著相关性（p>0.05 均）。然而，VAI 与精液参数、总血清睾酮和 T/E2 呈显著负相关（p<0.05 均）。此外，VAI 与总活力评分独立相关。VAI 所显示的内脏脂肪增加可能会由于其代谢和激素作用而对男性生育能力产生不利影响。由于不育是由不同的代谢状况引起的，因此可以从多学科的角度更好地理解潜在机制。
