Sears Clara G, Lanphear Bruce P, Calafat Antonia M, Chen Aimin, Skarha Julianne, Xu Yingying, Yolton Kimberly, Braun Joseph M
Department of Epidemiology, Brown University, Providence, Rhode Island 02912, United States.
Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Environ Sci Technol. 2020 Apr 7;54(7):4327-4335. doi: 10.1021/acs.est.9b04898. Epub 2020 Mar 9.
Dust in homes can contain phthalates that may adversely affect child development, but whether residential interventions and dust removal can prevent children's exposure to phthalates is unknown. We quantified the influence of a residential lead hazard intervention and dust control on children's urinary phthalate metabolite concentrations. Between 2003 and 2006, The Health Outcomes and Measures of the Environment (HOME) Study randomized 355 pregnant women to receive an intervention to reduce either residential lead or injury hazards before delivery. We quantified eight urinary phthalate metabolites from 288 children at ages 1, 2, or 3 years (680 observations). During yearly home visits, we assessed dust accumulation in housing units. Children in the lead intervention group had 11-12% lower concentrations of the sum of di(2-ethylhexyl) phthalate metabolites, monocarboxyoctyl phthalate, and monocarboxynonyl phthalate compared to the injury intervention group. Monoethyl phthalate concentrations did not differ by group. In observational analyses, children living in housing units that appeared clean had 12-17% lower concentrations of these phthalate metabolites and monobenzyl phthalate, compared to children living in housing units with more dust accumulation. Features of this lead hazard intervention and measures to control dust may reduce children's exposure to phthalates found in building materials and household furnishings.
家庭灰尘中可能含有邻苯二甲酸盐，这可能会对儿童发育产生不利影响，但住宅干预和除尘是否能防止儿童接触邻苯二甲酸盐尚不清楚。我们量化了住宅铅危害干预和灰尘控制对儿童尿邻苯二甲酸酯代谢物浓度的影响。2003年至2006年期间，健康结果与环境测量（HOME）研究将355名孕妇随机分为两组，一组在分娩前接受减少住宅铅危害的干预，另一组接受减少伤害危害的干预。我们对288名1岁、2岁或3岁儿童的8种尿邻苯二甲酸酯代谢物进行了量化（共680次观察）。在每年的家访中，我们评估了住房单元中的灰尘积累情况。与伤害干预组相比，铅干预组儿童的邻苯二甲酸二（2-乙基己基）酯代谢物、单羧基辛基邻苯二甲酸酯和单羧基壬基邻苯二甲酸酯总和浓度低11%-12%。邻苯二甲酸单乙酯浓度在两组间无差异。在观察性分析中，与生活在灰尘积累较多的住房单元中的儿童相比，生活在看起来干净的住房单元中的儿童这些邻苯二甲酸酯代谢物和单苄基邻苯二甲酸酯的浓度低12%-17%。这种铅危害干预措施和灰尘控制措施可能会减少儿童接触建筑材料和家居用品中邻苯二甲酸盐的机会。
