Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Science. 2019 Mar 22;363(6433):1345-1349. doi: 10.1126/science.aat8515.
Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and the tumors transported both sugars. Within the tumors, fructose was converted to fructose-1-phosphate, leading to activation of glycolysis and increased synthesis of fatty acids that support tumor growth. These mouse studies support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis.
过量饮用高果糖玉米糖浆（HFCS）饮料与肥胖和结直肠癌风险增加有关。HFCS 是否直接促进肿瘤发生尚不清楚。我们研究了 HFCS 对腺瘤性结肠息肉病（APC）突变小鼠的每日口服给药的影响，这些小鼠易发生肠道肿瘤。在没有肥胖和代谢综合征的情况下，HFCS 处理的小鼠的肿瘤大小和肿瘤分级均显著增加。HFCS 分别增加了肠道腔和血清中的果糖和葡萄糖浓度，肿瘤也转运这两种糖。在肿瘤内，果糖转化为果糖-1-磷酸，导致糖酵解激活和支持肿瘤生长的脂肪酸合成增加。这些小鼠研究支持这样一种假说，即饮食中葡萄糖和果糖的组合，即使是中等剂量，也可以增强肿瘤发生。
