Institute of Advanced Composite Materials, Korea Institute of Science and Technology, 92 Chudong-ro, Bongdong-eup, Wanju-gun, Jeollabuk-do 55324, Korea.
Department of Bioactive Material Sciences, Chonbuk National University, 567 Baekje-daero, Jeonju, Jeollabuk-do 54896, Korea.
Int J Mol Sci. 2020 Feb 24;21(4):1529. doi: 10.3390/ijms21041529.
Commercially available boron nitride nanotubes (BNNTs) and their purified form (pBNNTs) were dispersed in aqueous solutions with various dispersants, and their cytotoxicity and drug encapsulation capacity were monitored. Our data suggest that pBNNTs showed an average increase in dispersibility of 37.3% in aqueous solution in the presence of 10 different dispersants. In addition, 100 μg of pBNNTs induced an average decrease in cytotoxicity of 27.4% compared to same amount of BNNTs in normal cell lines. The same amount of pBNNTs can encapsulate 10.4-fold more drug (camptothecin) compared to BNNTs. These data suggest that the purification of BNNTs improves several of their properties, which can be applied to biological experiments and are thus essential in the biological application of BNNTs.
市售氮化硼纳米管（BNNTs）及其纯化形式（pBNNTs）与各种分散剂分散在水溶液中，并监测其细胞毒性和药物包封能力。我们的数据表明，在 10 种不同分散剂的存在下，pBNNTs 在水溶液中的分散性平均提高了 37.3%。此外，与相同数量的 BNNTs 在正常细胞系中相比，100μg 的 pBNNTs 可使细胞毒性平均降低 27.4%。相同数量的 pBNNTs 可以比 BNNTs 多包封 10.4 倍的药物（喜树碱）。这些数据表明，BNNTs 的纯化提高了其多项性能，可应用于生物学实验，因此在 BNNTs 的生物学应用中是必不可少的。
