Javed Zeeshan, Ahmed Shah Faiez, Rajabi Sadegh, Raza Qamar, Iqbal Zaheer, Ullah Mukhtar, Ahmad Touqeer, Salehi Bahare, Sharifi-Rad Mehdi, Pezzani Raffaele, Yaqoob Farooq, Sadia Haleema, Iriti Marcello, Sharifi-Rad Javad, Cho William C
Office for Research Innovation and Commercialization Lahore Garrison University, Lahore, Pakistan.
Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan.
Asian Pac J Cancer Prev. 2020 Feb 1;21(2):281-287. doi: 10.31557/APJCP.2020.21.2.281.
Thyroid cancer (TC) is the most common cancer of endocrine system. TC can be subdivided into 4 different entities, papillary, follicular, medullary and anaplastic thyroid cancer. Among them, anaplastic thyroid cancer has the poorest prognosis. Exploring new therapeutic approach may entail favorable prediction as well as increasing overall survival rate of patients. Long non-coding RNAs (lncRNAs), have vast implications in different cancer types. Although they are not transcribed into proteins, they can act as a harness in regulating a plethora of biological functions. They have been implicated in a decisive role in gene expression via modulation of both coding and non-coding RNAs. This article discuss the multi-facet role of lncRNA in thyroid cancer biology.
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甲状腺癌（TC）是内分泌系统最常见的癌症。甲状腺癌可细分为4种不同类型，即乳头状癌、滤泡状癌、髓样癌和未分化甲状腺癌。其中，未分化甲状腺癌的预后最差。探索新的治疗方法可能需要良好的预测并提高患者的总体生存率。长链非编码RNA（lncRNAs）在不同类型的癌症中具有广泛影响。虽然它们不转录为蛋白质，但可作为调节多种生物学功能的一种手段。它们通过调节编码和非编码RNA在基因表达中发挥决定性作用。本文讨论lncRNA在甲状腺癌生物学中的多方面作用。
