Department of Ophthalmology, The First People's Hospital of Yancheng, No. 10, Nancheng River Road, Yancheng, 224000, Jiangsu Province, China.
Department of Ophthalmology, Yangzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yangzhou, 225000, Jiangsu Province, China.
Int Ophthalmol. 2020 Jun;40(6):1587-1601. doi: 10.1007/s10792-020-01325-4. Epub 2020 Feb 26.
To review the role of inflammatory mediators in proliferative vitreoretinopathy (PVR) development and the current treatment for PVR prevention.
A PubMed search was carried out using these keywords "PVR," "inflammatory mediators," "growth factors," "cytokines" and "treatment." Studies regarding inflammatory mediators and PVR therapy were included and published up to December 2019.
Inflammatory mediators, namely growth factors and cytokines, have been implicated in the occurrence and development of PVR. Among various inflammatory mediators, transforming growth factor-β, platelet-derived growth factor, interleukin-6, interleukin-8 and tumor necrosis factor-α are considered to be particularly important. In this review, we focus on the hypothesis that growth factors and cytokines are involved in the development of PVR, and current treatment for the prevention of PVR.
We support the hypothesis that growth factors and cytokines may participate in the complex process of PVR development. More importantly, the identification of inflammatory mediators provides novel and efficacious therapeutic targets for the treatment of PVR.
回顾炎症介质在增生性玻璃体视网膜病变（PVR）发展中的作用，以及目前用于预防 PVR 的治疗方法。
使用“PVR”、“炎症介质”、“生长因子”、“细胞因子”和“治疗”这些关键词在 PubMed 上进行搜索。纳入并分析了关于炎症介质与 PVR 治疗的研究，这些研究的发表时间截至 2019 年 12 月。
炎症介质，即生长因子和细胞因子，与 PVR 的发生和发展有关。在各种炎症介质中，转化生长因子-β、血小板衍生生长因子、白细胞介素-6、白细胞介素-8 和肿瘤坏死因子-α被认为尤为重要。在本综述中，我们关注的是生长因子和细胞因子参与 PVR 发展的假说，以及当前预防 PVR 的治疗方法。
我们支持生长因子和细胞因子可能参与 PVR 发展这一复杂过程的假说。更重要的是，炎症介质的鉴定为 PVR 的治疗提供了新的、有效的治疗靶点。
