Microglia Research in the 100th Year Since Its Discovery.
作者信息
Umpierre Anthony D, Wu Long-Jun
机构信息
Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
出版信息
Neurosci Bull. 2020 Mar;36(3):303-306. doi: 10.1007/s12264-020-00477-8. Epub 2020 Feb 26.
Abstract
摘要
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本文引用的文献
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Cell. 2019 Dec 12;179(7):1609-1622.e16. doi: 10.1016/j.cell.2019.11.010.
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Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.小胶质细胞通过专门的体部嘌呤能接头来监测和保护神经元功能。
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Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain.人诱导多能干细胞衍生的小胶质细胞在移植到新生小鼠大脑后呈现出初级小胶质细胞样状态。
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NLRP3 inflammasome activation drives tau pathology.NLRP3 炎性小体激活驱动 tau 病理。
Nature. 2019 Nov;575(7784):669-673. doi: 10.1038/s41586-019-1769-z. Epub 2019 Nov 20.
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Mapping microglia states in the human brain through the integration of high-dimensional techniques.通过整合高维技术绘制人类大脑中的小胶质细胞状态图。
Nat Neurosci. 2019 Dec;22(12):2098-2110. doi: 10.1038/s41593-019-0532-y. Epub 2019 Nov 18.
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Stem-cell-derived human microglia transplanted in mouse brain to study human disease.将源自干细胞的人类小神经胶质细胞移植到老鼠大脑中，以研究人类疾病。
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A Microglia Sublineage Protects from Sex-Linked Anxiety Symptoms and Obsessive Compulsion.一种小胶质细胞亚群可预防性连锁焦虑症状和强迫症。
Cell Rep. 2019 Oct 22;29(4):791-799.e3. doi: 10.1016/j.celrep.2019.09.045.
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Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex.觉醒状态下的去甲肾上腺素信号抑制小鼠视觉皮层小胶质细胞的监视和突触可塑性。
Nat Neurosci. 2019 Nov;22(11):1782-1792. doi: 10.1038/s41593-019-0514-0. Epub 2019 Oct 21.
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Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling.神经元网络活动通过去甲肾上腺素信号控制清醒小鼠小胶质细胞的过程监测。
Nat Neurosci. 2019 Nov;22(11):1771-1781. doi: 10.1038/s41593-019-0511-3. Epub 2019 Oct 21.
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Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.体内研究和操纵人类小胶质细胞的嵌合模型的开发。
Neuron. 2019 Sep 25;103(6):1016-1033.e10. doi: 10.1016/j.neuron.2019.07.002. Epub 2019 Jul 30.
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