Liu Zhe, Shen Tiefeng, Wei Dawei, Yu Yong, Huang Desheng, Guan Peng
Department of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning, People's Republic of China.
Division of Infectious Disease Control, Huludao Municipal Center for Disease Control and Prevention, Huludao, Liaoning, People's Republic of China.
Infect Drug Resist. 2020 Feb 11;13:435-445. doi: 10.2147/IDR.S236326. eCollection 2020.
To describe the incidence trend, demographic and clinical characteristics, treatment and prognosis, epidemiological history and risk factors of human brucellosis in Huludao, China.
A total of 1887 brucellosis patients were reported in Huludao, China from January, 2014 to December, 2018 and the case questionnaires from 1149 patients were collected from Huludao Municipal Center for Disease Control and Prevention. Demographic characteristics of the patients and the information relating to the patients' clinical manifestations, diagnosis, treatment and prognosis were collected and analyzed.
The number of annually reported brucellosis patients has dropped from 711 to 187 during the study period, with the incidence decreased from 27.31/100,000 in 2014 to 7.15/100,000 in 2018. A total of 1149 individual data were collected, with a mean age of 49.59±13.14 years and 75.7% were male. Patients aged more than 60 years were more likely to have arthralgia/myalgia than the other age groups, and patients who had an enlarged spleen in male were more than female (<0.05). There were more acute brucellosis cases, less sub-acute and chronic brucellosis cases in the ethnic minority (83.6%, 5.5% and 11.0%, respectively) than that in the Han nationality (64.7%, 22.2% and 13.0%, respectively, <0.05). For antibiotic therapy, "Doxycycline plus rifampicin or streptomycin" was the most commonly used drug combination. Sheep/goat was the main contacted animal and feeding/grazing was the most frequent transmission route; no personal protective measures were the major risk factor.
The incidence of human brucellosis is still high in Huludao, China, and this is mostly associated with contacting with domestic animals and barely taking protective measures. The most common clinical manifestations of brucellosis patients in Huludao were fatigue, hyperhidrosis, fever, and arthralgia/myalgia, the most common route of exposure was feeding and grazing, and the major species of livestock was sheep/goat. The most commonly adopted treatment option was antibiotic therapy, and most patients responded well to treatment. The integrality and accuracy of the notifiable epidemiological case questionnaire needs to be improved in order to provide more factual and objective information for both the physicians and policy-makers.
描述中国葫芦岛市人间布鲁氏菌病的发病趋势、人口统计学和临床特征、治疗与预后、流行病学史及危险因素。
收集了2014年1月至2018年12月中国葫芦岛市报告的1887例布鲁氏菌病患者信息，并从葫芦岛市疾病预防控制中心获取了1149例患者的病例调查问卷。收集并分析了患者的人口统计学特征以及与患者临床表现、诊断、治疗和预后相关的信息。
研究期间每年报告的布鲁氏菌病患者数量从711例降至187例，发病率从2014年的27.31/10万降至2018年的7.15/10万。共收集到1149份个体数据，平均年龄为49.59±13.14岁，男性占75.7%。60岁以上患者比其他年龄组更易出现关节痛/肌痛，男性脾肿大患者多于女性（<0.05）。少数民族急性布鲁氏菌病病例较多，亚急性和慢性病例较少（分别为83.6%、5.5%和11.0%），而汉族分别为64.7%、22.2%和13.0%（<0.05）。抗生素治疗方面，“多西环素加利福平或链霉素”是最常用的药物组合。羊/山羊是主要接触动物，饲养/放牧是最常见的传播途径；未采取个人防护措施是主要危险因素。
中国葫芦岛市人间布鲁氏菌病发病率仍较高，主要与接触家畜及几乎未采取防护措施有关。葫芦岛市布鲁氏菌病患者最常见的临床表现为乏力、多汗、发热和关节痛/肌痛，最常见的暴露途径是饲养和放牧，主要家畜种类是羊/山羊。最常用的治疗方法是抗生素治疗，大多数患者治疗反应良好。为给医生和政策制定者提供更真实客观的信息，需提高法定传染病流行病学个案调查问卷的完整性和准确性。
