Yang Dan, Deng Feiyang, Liu Dechun, He Bo, He Bing, Tang Xing, Zhang Qiang
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Asian J Pharm Sci. 2019 Jul;14(4):349-364. doi: 10.1016/j.ajps.2018.06.002. Epub 2018 Sep 14.
Aurum nanomaterials (ANM), combining the features of nanotechnology and metal elements, have demonstrated enormous potential and aroused great attention on biomedical applications over the past few decades. Particularly, their advantages, such as controllable particle size, flexible surface modification, higher drug loading, good stability and biocompatibility, especially unique optical properties, promote the development of ANM in biomedical field. In this review, we will discuss the advanced preparation process of ANM and summarize their recent applications as well as their prospects in diagnosis and therapy. Besides, multi-functional ANM-based theranostic nanosystems will be introduced in details, including radiotherapy (RT), photothermal therapy (PTT), photodynamic therapy (PDT), immunotherapy (IT), and so on.
金纳米材料（ANM）结合了纳米技术和金属元素的特性，在过去几十年里已展现出巨大潜力，并在生物医学应用方面引起了广泛关注。特别是，它们具有诸如可控粒径、灵活的表面修饰、更高的药物负载量、良好的稳定性和生物相容性等优点，尤其是独特的光学性质，推动了ANM在生物医学领域的发展。在本综述中，我们将讨论ANM的先进制备过程，总结其近期应用以及在诊断和治疗方面的前景。此外，还将详细介绍基于多功能ANM的治疗诊断纳米系统，包括放射治疗（RT）、光热疗法（PTT）、光动力疗法（PDT）、免疫疗法（IT）等。
