Lamichhane Shrawani, Bashyal Santosh, Keum Taekwang, Noh Gyubin, Seo Jo Eun, Bastola Rakesh, Choi Jaewoong, Sohn Dong Hwan, Lee Sangkil
College of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea.
Asian J Pharm Sci. 2019 Sep;14(5):465-479. doi: 10.1016/j.ajps.2018.11.008. Epub 2019 Feb 14.
3D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3D printing was developed in the 1980s and the technology has found widespread industrial applications for production from automotive parts to machine tools, its application in pharmaceutical area is still limited. However, the potential of 3D printing in the pharmaceutical industry is now being recognized. The ability of 3D printing to produce medications to exact specifications tailored to the needs of individual patients has indicated the possibility of developing personalized medicines. The technology allows dosage forms to be precisely printed in various shapes, sizes and textures that are difficult to produce using traditional techniques. However, there are various challenges associated with the proper application of 3D printing in the pharmaceutical sector which should be overcome to exploit the scope of this technology. In this review, an overview is provided on the various 3D printing technologies used in fabrication of complex dosage forms along with their feasibility and limitations.
3D打印是一种快速成型和制造方法，在该方法中，材料逐层沉积以制造三维物体。尽管3D打印技术于20世纪80年代问世，并且该技术在从汽车零部件到机床生产等广泛的工业应用中都有发现，但其在制药领域的应用仍然有限。然而，3D打印在制药行业的潜力目前正在得到认可。3D打印能够根据个体患者的需求生产出精确规格的药物，这表明了开发个性化药物的可能性。该技术允许以传统技术难以生产的各种形状、尺寸和质地精确打印剂型。然而，在制药领域正确应用3D打印存在各种挑战，要充分利用这项技术的范围就必须克服这些挑战。在这篇综述中，对用于制造复杂剂型的各种3D打印技术及其可行性和局限性进行了概述。
