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我们不擅长挑选候选基因,这拖慢了我们的进度。

We aren't good at picking candidate genes, and it's slowing us down.

机构信息

Donald Danforth Plant Science Center, United States.

出版信息

Curr Opin Plant Biol. 2020 Apr;54:57-60. doi: 10.1016/j.pbi.2020.01.006. Epub 2020 Feb 24.

DOI:10.1016/j.pbi.2020.01.006
PMID:32106014
Abstract

In order to gain a molecular understanding of the genetic basis for plant traits, we need to be able to identify the underlying gene and the causal allele for genetic loci. This process usually involves a step where a researcher selects likely candidate genes from a list. The process of picking candidate genes is inherently prone to distortion due to human bias, and this is slowing down our research enterprise.

摘要

为了从分子水平上理解植物性状的遗传基础,我们需要能够识别遗传位点的潜在基因和因果等位基因。这个过程通常涉及研究人员从基因列表中选择可能的候选基因。由于人类的偏见,选择候选基因的过程本身就容易出现偏差,这也减缓了我们的研究进程。

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