Göllnitz R, Lommatzsch P K
Augenklinik, Karl-Marx-Universität Leipzig.
Klin Monbl Augenheilkd. 1988 Jun;192(6):660-5. doi: 10.1055/s-2008-1050200.
Lymphocytic infiltration of melanomas represents an immunological response of the organism to the tumor. In order to establish the prognostic significance of this parameter, 369 cases of malignant choroidal melanoma were investigated in the study reported here with respect to the degree of infiltration. The relationship to survival time and other histopathological parameters was examined by means of the mortality tabulation method. The 84.5% five-year survival rate among patients with melanomas exhibiting intense infiltration was significantly higher than the 70.9% rate among patients with tumors showing little infiltration. This study statistically confirms current conjecture that the degree of lymphocytic infiltration, already proven to be prognostically significant in cutaneous melanoma, is also prognostically significant in choroidal melanoma. No correlations to other histopathological parameters could be demonstrated.
黑色素瘤中的淋巴细胞浸润代表机体对肿瘤的免疫反应。为了确定该参数的预后意义，在本文报道的研究中，对369例恶性脉络膜黑色素瘤的浸润程度进行了调查。通过死亡率列表法检查了其与生存时间和其他组织病理学参数的关系。黑色素瘤表现为强烈浸润的患者中，84.5%的五年生存率显著高于肿瘤浸润较少的患者中的70.9%。这项研究从统计学上证实了目前的推测，即淋巴细胞浸润程度在皮肤黑色素瘤中已被证明具有预后意义，在脉络膜黑色素瘤中也具有预后意义。未发现与其他组织病理学参数存在相关性。
