Davidorf F H, Lang J R
Trans Ophthalmol Soc U K (1962). 1977 Sep;97(3):394-401.
Lymphocytic and plasmacytic infiltration surrounding a malignant tumour probably represents an immunological response of the host directed against the neoplasm. Lymphocytic infiltration has a favourable effect on the prognosis in a number of human tunours, including cutaneous melanoma. The present study includes 326 consecutive cases of cholroidal melanoma which were examined for cellular infiltration. These data were then correlated with other histological parameters and with prognosis. An intense cellular infiltration was found in fifteen tumours (4.6 per cent) and a moderate infiltration in forty (12.3 per cent). Tumours with cellular infiltration were significantly larger and more vascularized than the remaining tumours, which may relate to the accessibility of the immune system to the tumour. There was a higher percentage of poorly differentiated tumours among those with cellular infiltration. However, it does not appear that cellular infiltration favourably influences the prognosis of choroidal melanoma, as 5-year survival rates did not correlate with the degree of cellular infiltration demonstrated by the primary tumour. Although choroidal melanomas are capable of inciting an immune response, this response is apparently ineffective in preventing metastastic spread.
恶性肿瘤周围的淋巴细胞和浆细胞浸润可能代表宿主针对肿瘤的免疫反应。淋巴细胞浸润对包括皮肤黑色素瘤在内的多种人类肿瘤的预后具有有利影响。本研究纳入了326例连续的脉络膜黑色素瘤病例，对其进行细胞浸润检查。然后将这些数据与其他组织学参数及预后进行关联分析。在15个肿瘤（4.6%）中发现有强烈的细胞浸润，40个肿瘤（12.3%）中有中度浸润。有细胞浸润的肿瘤比其余肿瘤明显更大且血管更丰富，这可能与免疫系统对肿瘤的可达性有关。在有细胞浸润的肿瘤中，低分化肿瘤的比例更高。然而，细胞浸润似乎并未对脉络膜黑色素瘤的预后产生有利影响，因为5年生存率与原发肿瘤所显示的细胞浸润程度并无关联。尽管脉络膜黑色素瘤能够激发免疫反应，但这种反应显然在预防转移扩散方面无效。
