Lang J R, Davidorf F H, Baba N
Cancer. 1977 Nov;40(5):2388-94. doi: 10.1002/1097-0142(197711)40:5<2388::aid-cncr2820400556>3.0.co;2-o.
Lymphocytic and plasmocytic infiltration surrounding a malignant tumor probably represents an immunologic response of the host directed against the neoplasm. It has been documented that lymphocytic infiltration has a favorable effect on prognosis in a number of human tumor systems, including cutaneous melanoma. In the present study, 309 consecutive cases of choroidal melanoma were examined for cellular infiltration, and these data were correlated with other histologic parameters and with prognosis. A intense cellular infiltration was found in 15 tumors (4.9%) and a moderate infiltration in 37 (12.0%). Tumors with cellular infiltration were significantly larger and more vascularized than the remaining tumors, which may be related to the accessibility of the immune system to the tumor. There was a higher percentage of poorly differentiated tumors among the tumors with cellular infiltration. However, it does not appear the cellular infiltration favorably influences the prognosis of choroidal melanoma. The 5-year survival rates of patients with like cell types did not depend upon the degree of cellular infiltration demonstrated by the primary tumor. Although choroidal melanomas are capable of inciting an immune response, this response is apparently ineffective in preventing metastatic spread.
恶性肿瘤周围的淋巴细胞和浆细胞浸润可能代表宿主针对肿瘤的免疫反应。已有文献证明，淋巴细胞浸润对包括皮肤黑色素瘤在内的多种人类肿瘤系统的预后有有利影响。在本研究中，对309例连续的脉络膜黑色素瘤病例进行了细胞浸润检查，并将这些数据与其他组织学参数及预后相关联。在15个肿瘤（4.9%）中发现有强烈的细胞浸润，37个肿瘤（12.0%）中有中度浸润。有细胞浸润的肿瘤比其余肿瘤明显更大且血管更丰富，这可能与免疫系统对肿瘤的可达性有关。在有细胞浸润的肿瘤中，低分化肿瘤的比例更高。然而，细胞浸润似乎并未对脉络膜黑色素瘤的预后产生有利影响。具有相同细胞类型的患者的5年生存率并不取决于原发肿瘤所显示的细胞浸润程度。尽管脉络膜黑色素瘤能够激发免疫反应，但这种反应显然在预防转移扩散方面无效。
