Research Department, Omnica Co., Ltd, 4-21-7 Itabashi, Itabashi ward, Tokyo, 173-0004, Japan.
Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo 002-8072, Japan.
Nutrients. 2020 Feb 25;12(3):600. doi: 10.3390/nu12030600.
A 12-week-long randomized, double-blind, placebo-controlled, parallel-group comparison trial was conducted to determine the effects of long-term standardized bilberry extract (SBE) intake on tonic accommodation of ciliary muscle caused by visual display terminal (VDT) tasks. This study was compliant with the accordance with CONSORT 2010 statement. A total of 109 healthy adult men and women aged 20-60 years were recruited and randomized into SBE and placebo groups. The subjects in the SBE and placebo groups were administered 240 mg of SBE and placebo, respectively, once daily for 12 weeks. Tests were performed before and after VDT tasks at week 0, 4, 8, and 12; high-frequency component (HFC)-1 value was the evaluation outcome. Results showed that post-load HFC-1 values at weeks 8 and 12 were significantly improved in the SBE group than in the placebo group ( = 0.014 and 0.017, respectively). Regarding the difference between before and after the task load (ΔHFC-1), the values were significantly better in the SBE group than in the placebo group at week 4 and 12 ( = 0.018 and 0.049, respectively). This study shows that oral consumption of 240 mg SBE extract for 12 weeks relieves the tonic accommodation of the ciliary muscle caused by VDT tasks and near-vision tasks.
一项为期 12 周的随机、双盲、安慰剂对照、平行组比较试验旨在确定长期标准化越橘提取物（SBE）摄入对视讯终端（VDT）任务引起的睫状肌紧张性调节的影响。本研究符合 CONSORT 2010 声明的规定。共招募了 109 名年龄在 20-60 岁的健康成年男女，并将其随机分为 SBE 和安慰剂组。SBE 和安慰剂组的受试者分别每天服用 240mg 的 SBE 和安慰剂，持续 12 周。在 0、4、8 和 12 周进行 VDT 任务前后进行测试；高频成分（HFC）-1 值是评估结果。结果显示，在第 8 周和第 12 周，SBE 组的后负荷 HFC-1 值明显高于安慰剂组（=0.014 和 0.017）。关于任务负荷前后的差异（ΔHFC-1），SBE 组在第 4 周和第 12 周的改善明显优于安慰剂组（=0.018 和 0.049）。本研究表明，口服 240mg SBE 提取物 12 周可缓解 VDT 任务和近距视觉任务引起的睫状肌紧张性调节。
