Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Endocrinol (Lausanne). 2022 Jun 13;13:890305. doi: 10.3389/fendo.2022.890305. eCollection 2022.
Serum uric acid (SUA) is associated with many cardiovascular risk factors, such as metabolic syndrome (MetS) and subclinical atherosclerosis. However, the relationship of SUA with carotid atherosclerosis remains controversial. We aimed to investigate whether elevated SUA levels are associated with a high risk of carotid atherosclerosis and MetS in patients with type 2 diabetes mellitus (T2DM).
This cross-sectional study was performed with a sample of 1,947 hospitalized patients with T2DM. Carotid intima-media thickness and carotid artery plaques were measured Doppler ultrasound.
Uric acid levels were negatively associated with HbA1C, eGFR, and HDL-C (all P < 0.001) and positively associated with WBC, BMI, ACR, creatinine, total cholesterol, triglycerides, LDL-C, systolic blood pressure, and diastolic blood pressure (all P < 0.001). After adjusting for multiple potential confounders, the risks were substantially higher for MetS in the highest quartile of SUA levels (odds ratio: 2.91, 95% confidence interval: 1.54-5.51, P = 0.003 for trend) than in the lowest quartile of SUA levels. Furthermore, a significant increase was observed in the prevalence of overweight/obesity, hypertension, and dyslipidemia across the SUA quartiles independent of confounders. However, no significant association was found between SUA quartile with the presence of carotid atherosclerosis.
In patients with T2DM, SUA levels were closely associated with MetS and its components but not with carotid atherosclerosis.
血清尿酸（SUA）与许多心血管危险因素相关，如代谢综合征（MetS）和亚临床动脉粥样硬化。然而，SUA 水平与颈动脉粥样硬化的关系仍存在争议。我们旨在研究在 2 型糖尿病（T2DM）患者中，SUA 水平升高是否与颈动脉粥样硬化和 MetS 风险增加相关。
本横断面研究纳入了 1947 例住院 T2DM 患者。采用多普勒超声测量颈动脉内膜中层厚度和颈动脉斑块。
尿酸水平与 HbA1C、eGFR 和 HDL-C 呈负相关（均 P<0.001），与 WBC、BMI、ACR、肌酐、总胆固醇、甘油三酯、LDL-C、收缩压和舒张压呈正相关（均 P<0.001）。在调整了多个潜在混杂因素后，SUA 水平最高四分位数的 MetS 风险显著升高（比值比：2.91，95%置信区间：1.54-5.51，P=0.003 趋势），低于 SUA 水平最低四分位数。此外，在独立于混杂因素的情况下，SUA 四分位数与超重/肥胖、高血压和血脂异常的患病率呈显著增加趋势。然而，SUA 四分位数与颈动脉粥样硬化的存在之间没有显著关联。
在 T2DM 患者中，SUA 水平与 MetS 及其成分密切相关，但与颈动脉粥样硬化无关。
