State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Department of Hepatic-Biliary-Pancreatic Center, Zhongda Hospital, Southeast University, Nanjing, China.
J Cancer Res Clin Oncol. 2020 Apr;146(4):875-882. doi: 10.1007/s00432-020-03163-4. Epub 2020 Feb 27.
Presently, liver cancer is still one of the malignant tumors with high mortality. As far as the treatment of liver cancer is concerned, the most effective method is still liver transplantation. But every year, many liver cancer patients die from the lack of a proper liver transplant, or from waiting for a liver transplant. Therefore, it is very important to find new and effective treatment for patients with liver cancer.
Herein, the cell model and the orthotropic liver tumor mice model have been performed to verify the results of our treatment. We found that the in situ synthesized gold nanocluster-PTEN (GNC-PTEN) complexes can effectively target and realize the fluorescence imaging of the liver tumor.
GNC-PTEN complexes could inhibit the proliferation, invasion, and metastasis of liver cancer cells. And the results also showed that GNC-PTEN complexes could be well targeted liver tumor at 6 h and the liver tumor in mice group treated with GNC-PTEN complexes almost disappeared.
This is a simply and effectively method to realize liver cancer imaging and inhibition. This may raise the possibility for the accurate image/diagnosis and simultaneously efficient treatment of liver cancer in the relevant clinic application.
目前，肝癌仍是死亡率较高的恶性肿瘤之一。就肝癌的治疗而言，最有效的方法仍是肝移植。但每年都有许多肝癌患者因缺乏合适的肝移植或等待肝移植而死亡。因此，为肝癌患者找到新的有效治疗方法非常重要。
本文通过细胞模型和原位肝肿瘤小鼠模型验证了我们的治疗结果。我们发现，原位合成的金纳米簇-PTEN（GNC-PTEN）复合物可以有效地靶向和实现肝肿瘤的荧光成像。
GNC-PTEN 复合物能抑制肝癌细胞的增殖、侵袭和转移。结果还表明，GNC-PTEN 复合物在 6 小时内可很好地靶向肝肿瘤，且用 GNC-PTEN 复合物处理的小鼠组的肝肿瘤几乎消失。
这是一种简单有效的实现肝癌成像和抑制的方法。这可能为肝癌的准确成像/诊断和同时的有效治疗提供可能性，以便在相关临床应用中实现。
