Department of Dermatology, Dokkyo Medical University, School of Medicine, Shimotsuga, Tochigi, Japan.
Department of Dermatology, Dokkyo Medical University, School of Medicine, Shimotsuga, Tochigi, Japan.
J Invest Dermatol. 2020 Oct;140(10):2001-2008. doi: 10.1016/j.jid.2020.01.028. Epub 2020 Feb 25.
Potassium iodide (KI), initially derived from seaweed in the early 19th century, is used for treating sporotrichosis in dermatological practice. KI has also been used to treat several noninfectious inflammatory skin diseases. However, the mechanisms underlying the improvement in such skin diseases remain unknown, and KI is not used widely. Thus, although KI is an old drug, physicians may not prescribe it frequently because they lack knowledge about it. Although KI is very inexpensive and causes few side effects, it has been superseded by new powerful and expensive drugs, such as biological agents. We applied 3% KI topically to areas of inflammation induced by SDS in mice. The levels of IL-1 and TNF-α gene expression were reduced, whereas that of IL-10 gene expression was increased. Small interfering RNA that was designed to reduce IL-10 gene expression levels was injected into the same mice, and the anti-inflammatory effects of KI were not observed. Thus, the pharmacologic action of KI is based on its anti-inflammatory effects caused by the increase in IL-10 levels. This information would increase dermatologists' awareness of KI as an efficacious and cost-effective treatment.
碘化钾（KI）最初于 19 世纪初从海藻中提取，用于治疗皮肤科中的孢子丝菌病。KI 还用于治疗几种非传染性炎症性皮肤病。然而，其改善此类皮肤病的机制尚不清楚，因此 KI 并未广泛使用。尽管 KI 是一种古老的药物，但由于缺乏相关知识，医生可能不会经常开具该药。尽管 KI 非常便宜且副作用很少，但它已被新型强效且昂贵的药物（如生物制剂）所取代。我们将 3%的 KI 局部应用于 SDS 诱导的炎症小鼠模型中，发现 IL-1 和 TNF-α 基因表达水平降低，而 IL-10 基因表达水平升高。将设计用于降低 IL-10 基因表达水平的小干扰 RNA 注射到相同的小鼠中，观察不到 KI 的抗炎作用。因此，KI 的药理作用基于其通过增加 IL-10 水平而产生的抗炎作用。这些信息将提高皮肤科医生对 KI 作为一种有效且具有成本效益的治疗方法的认识。
