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载卟啉光敏剂和碘化钾的胶束的光动力疗效对耐药黑素瘤细胞的影响。

The Photosensitizing Efficacy of Micelles Containing a Porphyrinic Photosensitizer and KI against Resistant Melanoma Cells.

机构信息

Department of Physics and Chemistry, Faculty of, Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal.

出版信息

Chemistry. 2021 Jan 26;27(6):1990-1994. doi: 10.1002/chem.202004389. Epub 2021 Jan 12.

DOI:10.1002/chem.202004389
PMID:33185284
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7921759/
Abstract

Photodynamic therapy (PDT) is a promising alternative to overcome the resistance of melanoma to conventional therapies. Currently applied photosensitizers (PS) are often based on tetrapyrrolic macrocycles like porphyrins. Unfortunately, in some cases the use of this type of derivative is limited due to their poor solubility in the biological environment. Feasible approaches to surpass this drawback are based on lipid formulations. Besides that, and inspired in the efficacy of potassium iodide (KI) for antimicrobial photodynamic therapy (aPDT), the combined effect of singlet oxygen ( O ) with KI was assessed in this work, as an alternative strategy to potentiate the effect of PDT against resistant melanoma cells.

摘要

光动力疗法 (PDT) 是克服黑色素瘤对传统疗法耐药性的一种很有前途的替代方法。目前应用的光敏剂 (PS) 通常基于四吡咯大环化合物，如卟啉。不幸的是，在某些情况下，由于它们在生物环境中的溶解度差，这种类型的衍生物的使用受到限制。克服这一缺点的可行方法是基于脂质制剂。此外，受碘化钾 (KI) 对抗菌光动力疗法 (aPDT) 的功效的启发，本工作评估了单线态氧 ( O ) 与 KI 的联合作用，作为增强 PDT 对耐药黑色素瘤细胞疗效的替代策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/7921759/af5491fbde90/nihms-1665297-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/7921759/084398aa60a9/nihms-1665297-f0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/7921759/dc6bd9fdb26b/nihms-1665297-f0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/7921759/084398aa60a9/nihms-1665297-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/7921759/3e1b4cab93de/nihms-1665297-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/7921759/1c0de86e14bd/nihms-1665297-f0003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/7921759/af5491fbde90/nihms-1665297-f0006.jpg

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