Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Avenue South, Nashville, TN 37240, USA.
Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Avenue South, Nashville, TN 37240, USA.
Sleep Med Rev. 2020 Jun;51:101282. doi: 10.1016/j.smrv.2020.101282. Epub 2020 Feb 11.
Although sleep disturbance is implicated in psychopathology, its role in anxiety-related disorders remains unclear. The present meta-analysis characterizes sleep disturbance in anxiety-related disorders collectively and individually. Subjective measures of total sleep time and sleep continuity were included with objective measures. Results indicate a large effect for increased subjective sleep disturbance (g = 2.16), medium effects for decreased total sleep time (g = -.40) and sleep continuity (g = -.49), and a small effect for decreased sleep depth (g = -.20) in anxiety-related disorders compared to healthy controls. Each anxiety-related disorder exhibited a distinct sleep disturbance pattern, suggesting that sleep may facilitate identification of unique biopsychological underpinnings. Effects were not moderated by comorbid depression and were similar in magnitude to those found for depression. Sleep disturbances, particularly decreased sleep continuity, may be a key pathology in the anxiety-related disorders that could highlight novel etiological mechanisms and intervention targets.
尽管睡眠障碍与精神病理学有关，但它在焦虑相关障碍中的作用仍不清楚。本荟萃分析综合和单独描述了焦虑相关障碍中的睡眠障碍。包括主观的总睡眠时间和睡眠连续性测量以及客观的测量。结果表明，与健康对照组相比，焦虑相关障碍中主观睡眠障碍（g=2.16）、总睡眠时间减少（g=-.40）和睡眠连续性减少（g=-.49）的效应较大，而睡眠深度减少（g=-.20）的效应较小。与健康对照组相比，每种焦虑相关障碍都表现出不同的睡眠障碍模式，这表明睡眠可能有助于确定独特的生物心理基础。抑郁共病并未调节这些效应，且其与抑郁的效应大小相似。睡眠障碍，特别是睡眠连续性的降低，可能是焦虑相关障碍的一个关键病理，这可能突出新的病因机制和干预靶点。
