Liu Hao-Wen, Liu Jia-Sin, Kuo Ko-Lin
Department of Family Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.
Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.
Tzu Chi Med J. 2019 Apr 23;32(1):65-69. doi: 10.4103/tcmj.tcmj_233_18. eCollection 2020 Jan-Mar.
Nonalcoholic fatty liver (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms and risk factors. The relationship between in NAFLD and CKD remains controversial. We aim to assess the association between NAFLD and CKD.
A cross-sectional study was based on individuals who received physical checkups at the Taipei Tzu Chi Hospital from September 5, 2005, to December 31, 2016. Demographic and clinical characteristics of the study population were collected. NAFLD was defined by abdominal ultrasonography and excluded other liver disease. CKD was defined as estimated glomerular filtration rate ≤60 mL/min/1.73 m or the presence of proteinuria. The association between NAFLD and CKD was then analyzed using SAS software by using the multivariable logistic model. A higher prevalence of CKD was shown in individuals with NAFLD compared to those without NAFLD.
In univariate analysis, individuals with mild NAFLD and moderate-to-severe NAFLD were both significantly associated with CKD (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.13-1.33; OR, 1.66; CI, 1.49-1.85) when compared to individuals without NAFLD. After multivariate adjustment, individuals with moderate-to-severe NAFLD were still significantly more likely to have CKD (OR, 1.17, 95% CI, 1.03-1.33).
Our finding showed that the presence and severity of NAFLD was positively associated with CKD in unadjusted and adjusted analysis. Further follow-up studies may be needed to validate these associations.
非酒精性脂肪性肝病（NAFLD）和慢性肾脏病（CKD）具有共同的致病机制和危险因素。NAFLD与CKD之间的关系仍存在争议。我们旨在评估NAFLD与CKD之间的关联。
一项横断面研究基于2005年9月5日至2016年12月31日在台北慈济医院接受体检的个体。收集研究人群的人口统计学和临床特征。NAFLD通过腹部超声检查定义，并排除其他肝脏疾病。CKD定义为估计肾小球滤过率≤60 mL/min/1.73 m²或存在蛋白尿。然后使用SAS软件通过多变量逻辑模型分析NAFLD与CKD之间的关联。与无NAFLD的个体相比，有NAFLD的个体中CKD的患病率更高。
在单变量分析中，与无NAFLD的个体相比，轻度NAFLD和中重度NAFLD个体均与CKD显著相关（比值比[OR]，1.23；95%置信区间[CI]，1.13 - 1.33；OR，1.66；CI，1.49 - 1.85）。经过多变量调整后，中重度NAFLD个体仍显著更易患CKD（OR，1.17，95% CI，1.03 - 1.33）。
我们的研究结果表明，在未调整和调整分析中，NAFLD的存在和严重程度与CKD呈正相关。可能需要进一步的随访研究来验证这些关联。
