Ahn Ah-Leum, Choi Jae-Kyung, Kim Mi-Na, Kim Seun-Ah, Oh Eun-Jung, Kweon Hyuk-Jung, Cho Dong-Yung
Department of Family Medicine, Konkuk University School of Medicine, Seoul, Korea.
Korean J Fam Med. 2013 May;34(3):199-205. doi: 10.4082/kjfm.2013.34.3.199. Epub 2013 May 24.
Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms and many risk factors, and both are linked to an increased risk of cardiovascular diseases. The aim of this study was to assess the association between NAFLD and CKD according to the presence of hypertension and diabetes mellitus in Koreans aged 50 years or older.
A cross-sectional study of 1,706 subjects who received their routine health examination was conducted between May 2008 and April 2010 at Konkuk University medical center. Biochemical tests for liver and abdominal ultrasonography were performed. CKD was defined as either proteinuria or glomerular filtration rate ≤60 mL/min per 1.73 m(2).
Among the 1,706 subjects, There were 545 (31.9%) with non-alcoholic fatty liver disease and 424 (24.9%) with chronic kidney disease. In univariate logistic regression analysis, NAFLD was significantly associated with CKD (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.34 to 2.12). In multivariate logistic regression analysis adjusted for age, sex, current smoking, abdominal obesity, aspartate aminotransferases, alanine aminotransferases, γ-glutamyltransferase, hypertension, diabetes mellitus, hypertriglyceridemia, and low high-density lipoprotein cholesterol, NAFLD was associated with CKD (adjusted OR, 1.68; 95% CI, 1.27 to 2.24). This relationship remained significant after classification according to the presence of hypertension or diabetes mellitus.
NAFLD diagnosed by ultrasonography was significantly associated with CKD in Koreans aged 50 years or older.
非酒精性脂肪性肝病（NAFLD）和慢性肾脏病（CKD）具有共同的致病机制和许多危险因素，且二者均与心血管疾病风险增加相关。本研究旨在评估50岁及以上韩国人中，根据高血压和糖尿病的存在情况，NAFLD与CKD之间的关联。
2008年5月至2010年4月期间，在建国大学医学中心对1706名接受常规健康检查的受试者进行了一项横断面研究。进行了肝脏生化检测和腹部超声检查。CKD定义为蛋白尿或肾小球滤过率≤60 mL/（min·1.73 m²）。
在1706名受试者中，有545名（31.9%）患有非酒精性脂肪性肝病，424名（24.9%）患有慢性肾脏病。在单因素逻辑回归分析中，NAFLD与CKD显著相关（比值比[OR]，1.69；95%置信区间[CI]，1.34至2.12）。在对年龄、性别、当前吸烟状况、腹型肥胖、天冬氨酸转氨酶、丙氨酸转氨酶、γ-谷氨酰转移酶、高血压、糖尿病、高甘油三酯血症和低高密度脂蛋白胆固醇进行校正的多因素逻辑回归分析中，NAFLD与CKD相关（校正OR，1.68；95% CI，1.27至2.24）。根据高血压或糖尿病的存在情况进行分类后，这种关系仍然显著。
通过超声诊断的NAFLD与50岁及以上韩国人的CKD显著相关。
