Department of Nutrition, School of Public Health, Fudan University, Shanghai 200032, China.
Department of Medicine, Nantong University Xinglin College, Nantong 226008, Jiangsu, China.
Int J Environ Res Public Health. 2020 Feb 26;17(5):1515. doi: 10.3390/ijerph17051515.
A genome-wide association study (GWAS) in the Han Chinese population had found that single nucleotide polymorphism (SNP) on the CMTM7 gene rs347134 was significantly associated with Body Mass Index (BMI). In the present study, the association of the rs347134 SNP with obesity and its interaction with dietary patterns (DPs) were explored in Han Chinese children. This cross-sectional study group included 1292 children, in whom obesity-related indicators were evaluated, the rs347134 SNP was genotyped by improved Multiple Ligase Detection Reaction (iMLDR), and the DPs were identified by principal component factor analysis. The GG genotype exhibited higher odds of general overweight/obesity (P = 0.038) and central obesity (P = 0.039) than AA+GA genotypes in boys. Four DPs of boys were identified: healthy balanced (HBDP), nuts and sweets-based (NSDP), animal food-based (AFDP), and wheaten and dairy-based (WDDP). Boys with the GG genotype were significantly more inclined to AFDP (P = 0.028) and had a shorter sleep duration (P = 0.031). Significant interactions were observed; boys with the GG genotype displayed a higher LDL in AFDP (P = 0.031) and higher FBG in NSDP (P = 0.038), respectively. Our findings indicate for the first time that the GG genotype of CMTM7 rs347134 is potentially a novel obesity risk factor for Han Chinese male children and is associated with dietary patterns more or less.
一项全基因组关联研究（GWAS）在汉族人群中发现，CMTM7 基因上的单核苷酸多态性（SNP）rs347134 与体重指数（BMI）显著相关。在本研究中，我们探讨了 rs347134 SNP 与肥胖的相关性及其与饮食模式（DPs）的相互作用。这项横断面研究纳入了 1292 名儿童，评估了肥胖相关指标，采用改良多重连接酶检测反应（iMLDR）检测 rs347134 SNP 基因型，通过主成分因子分析确定 DPs。在男孩中，GG 基因型与 AA+GA 基因型相比，更易出现全身性超重/肥胖（P = 0.038）和中心性肥胖（P = 0.039）。鉴定出男孩的 4 种 DPs：健康均衡（HBDP）、坚果和甜食（NSDP）、动物食品（AFDP）和面食和奶制品（WDDP）。携带 GG 基因型的男孩明显更倾向于食用 AFDP（P = 0.028），且睡眠时间更短（P = 0.031）。还观察到显著的相互作用；携带 GG 基因型的男孩在 AFDP 中 LDL 更高（P = 0.031），在 NSDP 中 FBG 更高（P = 0.038）。我们的研究结果首次表明，CMTM7 rs347134 的 GG 基因型可能是汉族男童肥胖的一个新的危险因素，并且或多或少与饮食模式有关。
