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[60例溃疡性结肠炎和克罗恩病患儿的随访]

[Follow-up of 60 children with ulcerative colitis and Crohn disease].

作者信息

Teufel M, Meyer-Hohnloser H, Mörcke E M, Stubig U, Niessen K H

机构信息

Universitäts-Kinderklinik, Mannheim.

出版信息

Monatsschr Kinderheilkd. 1988 Jul;136(7):378-83.

PMID:3211168
Abstract

The clinical courses of 60 children suffering from ulcerative Colitis (UC, n = 21) and Crohn's disease (CD, n = 39) were investigated over a period of 8.7 and 5.1 years respectively. At the time of diagnosis all UC-patients showed mucohemorrhagic feces. Relapses often occurred after emotional stress and in 81% of all patients during the winter season. Typical late complications were arthritis (6/21), osteoporosis (6/21), allergic diseases (8/21) and diabetes mellitus (2/21). However, the psychosomatic development appeared normal in at least 17/21 of these patients. Generally the courses in children with CD were more serious. Despite intensive therapy 15/39 children developed an intestinal stenosis which was followed by bowel resection in 11 of them. Further complications were fistulas (6/39), abscess-formations (4/39) and osteoporosis (12/39) due to steroid therapy. Only 12/39 showed a significant catch-up growth. Interviews and psychological tests revealed that CD-patients were introverted with strong connections to their families. Equally they longed for approval and social contact with their contemporaries.

摘要

分别对60例溃疡性结肠炎(UC,21例)和克罗恩病(CD,39例)患儿的临床病程进行了为期8.7年和5.1年的调查。诊断时,所有UC患儿均出现黏液血便。复发常发生在情绪应激后,且81%的患儿在冬季复发。典型的晚期并发症有关节炎(6/21)、骨质疏松(6/21)、过敏性疾病(8/21)和糖尿病(2/21)。然而,这些患儿中至少17/21的心理社会发育正常。总体而言,CD患儿的病程更为严重。尽管进行了强化治疗,15/39的患儿出现了肠道狭窄,其中11例随后接受了肠切除术。其他并发症包括瘘管(6/39)、脓肿形成(4/39)以及因类固醇治疗导致的骨质疏松(12/39)。只有12/39的患儿有显著的追赶生长。访谈和心理测试显示,CD患儿性格内向,与家人关系紧密。同样,他们渴望得到认可并与同龄人进行社交接触。

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