Department of Neurosurgery, Xiangya Hospital, Central South University (CSU), Changsha, China; Clinical Medicine Eight-year Program, Xiangya Medical School of Central South University, Changsha, Hunan, China.
Clinical Medicine Eight-year Program, Xiangya Medical School of Central South University, Changsha, Hunan, China; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Cancer Lett. 2020 May 1;477:31-40. doi: 10.1016/j.canlet.2020.02.027. Epub 2020 Feb 26.
Three-dimensional organoid culture systems show great promise as innovative physiological and pathophysiological models. Their applications in immunological research have been widely explored. For instance, immune organoids allow functional studies of immune system-related conditions, in a context that closely mimics the in vivo microenvironment, enabling an in-depth understanding of the immune tissue structures and functions. The newly developed coculture organoid and the air-liquid interface (ALI) systems also provided new insights for studying epithelia-immune cell interactions based on their endogenous distribution. Additionally, organoids have enabled the innovation of immunological disease models and exploration of the link between immunity and cancer, showing potential for personalized immunotherapy. This review is an overview of recent advances in the application of organoids in immunological research. Furthermore, the potential improvements for further utilization of organoids in personalized immunotherapy are discussed.
三维类器官培养系统作为创新的生理和病理生理学模型具有巨大的应用前景。它们在免疫学研究中的应用已被广泛探索。例如，免疫类器官允许在更接近体内微环境的情况下对免疫系统相关疾病进行功能研究，从而深入了解免疫组织的结构和功能。新开发的共培养类器官和气液界面（ALI）系统也基于其内在的分布为研究上皮细胞-免疫细胞相互作用提供了新的见解。此外，类器官还能够创新免疫性疾病模型，并探索免疫与癌症之间的联系，为个性化免疫治疗提供了潜在的可能性。本文综述了类器官在免疫学研究中的应用的最新进展。此外，还讨论了为进一步将类器官应用于个性化免疫治疗而进行的潜在改进。
