Department of Neurology, University of Ulm, Germany.
Institute of Epidemiology and Medical Biometry, University of Ulm, Germany.
Neuroimage Clin. 2020;26:102223. doi: 10.1016/j.nicl.2020.102223. Epub 2020 Feb 21.
The regional distribution of cerebral morphological alterations in primary lateral sclerosis (PLS) is considered to include the area III of the corpus callosum (CC).
The study was designed to investigate regional white matter (WM) alterations in the callosal area III by T1 weighted magnetic resonance imaging (T1w-MRI) data in PLS patients compared with healthy controls, in order to identify atrophy and texture changes in vivo.
T1w-MRI-based white matter mapping was used to perform an operator-independent CC-segmentation for the different areas of the CC in 67 PLS patients vs 82 matched healthy controls and vs 85 ALS patients. The segmentation was followed by texture analysis of the separated CC areas for the PLS patients vs controls and vs ALS patients.
PLS was associated with significant atrophy in the area III of the CC (but not in the other callosal segments), while the alterations in the ALS patients were much more variable and were not significant at the group level. Furthermore, significant regional alterations of the texture parameters entropy and homogeneity in this area were shown in PLS patients and in ALS patients.
This T1w-MRI study demonstrated focused regional CC atrophy and texture alterations limited to the callosal area III (which comprises fibers projecting into the primary motor cortices) in PLS, in comparison to a higher variability in CC size in ALS.
原发性侧索硬化症（PLS）的脑形态改变的区域分布被认为包括胼胝体（CC）的区域 III。
本研究旨在通过与健康对照组相比，在 PLS 患者中调查 CC 区域 III 的白质（WM）改变，以在体内识别萎缩和纹理变化。
使用 T1 加权磁共振成像（T1w-MRI）数据对 67 名 PLS 患者与 82 名匹配的健康对照组和 85 名 ALS 患者进行 T1w-MRI 基于白质的映射，以执行不同的 CC 区域的独立操作者的 CC 分割。对 PLS 患者与对照组和 ALS 患者进行分离的 CC 区域的纹理分析。
PLS 与 CC 区域 III 的明显萎缩相关（但与其他胼胝体段无关），而 ALS 患者的改变则更加多变，且在组水平上无显著差异。此外，在该区域显示出纹理参数熵和同质性的明显区域改变，在 PLS 患者和 ALS 患者中。
这项 T1w-MRI 研究表明，与 ALS 相比，PLS 中胼胝体的特定区域萎缩和纹理改变仅限于 CC 区域 III（包括投射到初级运动皮质的纤维），而 CC 大小的变异性更高。
