Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada, 2Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Canada.
Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada, 2Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Canada,
Front Biosci (Landmark Ed). 2020 Mar 1;25(8):1600-1616. doi: 10.2741/4869.
Reactive oxygen species (ROS) and iron play important roles in the innate immune response. ROS are released by immune cells and are highly reactive and indiscriminately destructive in response to pathogens. In addition, ROS act as signaling molecules and play a role in apoptosis, therefore excessive ROS production can damage host molecules, leading to more harm than benefit for the host. Iron acts as a catalyst for the formation of ROS, therefore, manipulation of iron levels is a way in controlling ROS production. Iron metabolism and ROS production may affect many disease processes and must be tightly regulated for the host to generate an appropriate response. Current researches examine the roles of iron and ROS in various conditions, including neurodegeneration, inflammation, infection and cancer. Therapies directed at regulating ROS production through regulating iron levels are a major focus in these fields today.
活性氧（ROS）和铁在先天免疫反应中起着重要作用。ROS 由免疫细胞释放，对病原体具有高度反应性和无差别破坏性。此外，ROS 作为信号分子发挥作用，并在细胞凋亡中发挥作用，因此过多的 ROS 产生会损害宿主分子，对宿主造成的伤害大于益处。铁作为 ROS 形成的催化剂，因此，操纵铁水平是控制 ROS 产生的一种方法。铁代谢和 ROS 产生可能会影响许多疾病过程，宿主必须进行严格调节以产生适当的反应。目前的研究检查了铁和 ROS 在各种情况下的作用，包括神经退行性变、炎症、感染和癌症。通过调节铁水平来调节 ROS 产生的疗法是这些领域的主要关注点。
