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葡萄籽原花青素提取物对肥胖的影响。

Effects of Grape Seed Proanthocyanidin Extract on Obesity.

作者信息

Liu Miao, Yun Peng, Hu Ying, Yang Jiao, Khadka Rim Bahadur, Peng Xiaochun

机构信息

Medical School of Yangtze University, Jingzhou, China.

Department of Endocrinology, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.

出版信息

Obes Facts. 2020;13(2):279-291. doi: 10.1159/000502235. Epub 2020 Feb 28.

DOI:10.1159/000502235
PMID:32114568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7250358/
Abstract

Obesity is a chronic metabolic disease resulting from excessive fat accumulation and/or abnormal distribution caused by multiple factors. As a major component of metabolic syndrome, obesity is closely related to many diseases such as type 2 diabetes mellitus, hyperlipidemia, hypertension, coronary heart disease, stroke and cancer. Hence, the problem of obesity cannot be ignored, and recent studies have shown that grape seed proanthocyanidin extract (GSPE) has an antiobesity effect. This paper systematically reviews the research progress and potential mechanism of GSPE emphasizing on obesity prevention and treatment.

摘要

肥胖是一种慢性代谢性疾病，由多种因素导致的脂肪过度堆积和/或分布异常引起。作为代谢综合征的主要组成部分，肥胖与许多疾病密切相关，如2型糖尿病、高脂血症、高血压、冠心病、中风和癌症。因此，肥胖问题不容忽视，最近的研究表明葡萄籽原花青素提取物（GSPE）具有抗肥胖作用。本文系统综述了GSPE在肥胖预防和治疗方面的研究进展及潜在机制。

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本文引用的文献

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Role of brown adipose tissue in modulating adipose tissue inflammation and insulin resistance in high-fat diet fed mice.棕色脂肪组织在高脂饮食喂养的小鼠脂肪组织炎症和胰岛素抵抗中的作用。
Eur J Pharmacol. 2019 Jul 5;854:354-364. doi: 10.1016/j.ejphar.2019.02.044. Epub 2019 Feb 27.
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Protective Effect of Proanthocyanidins in a Rat Model of Mild Intestinal Inflammation and Impaired Intestinal Permeability Induced by LPS.原花青素对 LPS 诱导的轻度肠道炎症和肠道通透性受损大鼠模型的保护作用。
Mol Nutr Food Res. 2019 Apr;63(8):e1800720. doi: 10.1002/mnfr.201800720. Epub 2019 Jan 23.
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[Importance of sleep and circadian rhythm for energy metabolism].[睡眠和昼夜节律对能量代谢的重要性]
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Alterations of circadian rhythms and their impact on obesity, metabolic syndrome and cardiovascular diseases.昼夜节律的改变及其对肥胖、代谢综合征和心血管疾病的影响。
Crit Rev Food Sci Nutr. 2020;60(6):1038-1047. doi: 10.1080/10408398.2018.1556579. Epub 2019 Jan 11.
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Links between the circadian rhythm, obesity and the microbiome.昼夜节律、肥胖与微生物群之间的联系。
Physiol Res. 2018 Nov 28;67(Suppl 3):S409-S420. doi: 10.33549/physiolres.934020.
6
Role of GSPE in improving early cerebral vascular damage by inhibition of Profilin-1 expression in a ouabain-induced hypertension model.白果酚醇提取物通过抑制哇巴因诱导高血压模型中 Profilin-1 的表达改善早期脑血管损伤的作用。
Eur Rev Med Pharmacol Sci. 2018 Oct;22(20):6999-7012. doi: 10.26355/eurrev_201810_16171.
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Behavioral and Pharmacotherapy Weight Loss Interventions to Prevent Obesity-Related Morbidity and Mortality in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.行为和药物治疗减肥干预措施预防成年人肥胖相关发病率和死亡率：美国预防服务工作组的更新证据报告和系统评价。
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Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet.肥胖相关的肠道微生物组失调与肠道通透性紊乱和肠道细胞内稳态失调有关，与饮食无关。
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Dietary grape seed procyanidin extract protects against lead-induced heart injury in rats involving endoplasmic reticulum stress inhibition and AKT activation.膳食葡萄籽原花青素提取物通过抑制内质网应激和激活 AKT 保护大鼠免受铅诱导的心脏损伤。
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The co-administration of proanthocyanidins and an obesogenic diet prevents the increase in intestinal permeability and metabolic endotoxemia derived to the diet.原花青素与致肥胖饮食共同给药可防止饮食引起的肠道通透性增加和代谢性内毒素血症。
J Nutr Biochem. 2018 Dec;62:35-42. doi: 10.1016/j.jnutbio.2018.07.012. Epub 2018 Aug 30.