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本文引用的文献

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Nonadherence to National Guidelines for Antibiotic Treatment of Uncomplicated Gonorrhea in China: Results From a Nationwide Survey.中国未遵循全国非复杂性淋病抗生素治疗指南：一项全国性调查的结果。
Sex Transm Dis. 2018 Sep;45(9):600-606. doi: 10.1097/OLQ.0000000000000819.
2
Cephalosporin-Resistant Neisseria gonorrhoeae Clone, China.头孢菌素耐药淋病奈瑟菌克隆，中国。
Emerg Infect Dis. 2018 Apr;24(4):804-806. doi: 10.3201/eid2404.171817.
3
Neisseria gonorrhoeae Sequence Typing for Antimicrobial Resistance, a Novel Antimicrobial Resistance Multilocus Typing Scheme for Tracking Global Dissemination of N. gonorrhoeae Strains.用于抗菌药物耐药性的淋病奈瑟菌序列分型，一种用于追踪淋病奈瑟菌菌株全球传播的新型抗菌药物耐药性多位点分型方案。
J Clin Microbiol. 2017 May;55(5):1454-1468. doi: 10.1128/JCM.00100-17. Epub 2017 Feb 22.
4
Neisseria gonorrhoeae strain with high-level resistance to spectinomycin due to a novel resistance mechanism (mutated ribosomal protein S5) verified in Norway.挪威证实淋病奈瑟菌由于新型耐药机制（核糖体蛋白 S5 突变）而对大观霉素高水平耐药。
Antimicrob Agents Chemother. 2013 Feb;57(2):1057-61. doi: 10.1128/AAC.01775-12. Epub 2012 Nov 26.
5
BIGSdb: Scalable analysis of bacterial genome variation at the population level.BIGSdb：在群体水平上对细菌基因组变异进行可扩展的分析。
BMC Bioinformatics. 2010 Dec 10;11:595. doi: 10.1186/1471-2105-11-595.
6
Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area.基于快速序列法对大城市地区淋球菌传播集群的鉴定
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Effect of spectinomycin use on the prevalence of spectinomycin-resistant and of penicillinase-producing Neisseria gonorrhoeae.使用壮观霉素对耐壮观霉素和产青霉素酶淋病奈瑟菌流行率的影响。
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中国一株高水平耐大观霉素耐药的多重耐药淋病奈瑟菌引起的淋菌性尿道炎。

Gonococcal urethritis caused by a multidrug resistant strain with high-level resistance to spectinomycin in China.

机构信息

Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, People's Republic of China.

National Center for STD Control, China Center for Disease Control and Prevention, Nanjing, People's Republic of China.

出版信息

Emerg Microbes Infect. 2020 Mar 2;9(1):517-519. doi: 10.1080/22221751.2020.1732836. eCollection 2020.

DOI:10.1080/22221751.2020.1732836
PMID:32116136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7067170/
Abstract

We report a recent (2018) gonorrhoeal urethritis caused by a multidrug-resistant strain in China. The isolated strain from a male and female pair expressed high-level resistance to spectinomycin (SPC), azithromycin, and other antibiotics but was sensitive to ceftriaxone. The SPC high-level resistance (MIC = 2048 mg/L) was due to a small deletion in that caused two amino acid changes in ribosomal protein S5.

摘要

我们报告了中国最近（2018 年）发生的一起由耐多药淋病奈瑟菌株引起的尿道炎。从一对男性和女性患者中分离出来的菌株对壮观霉素（SPC）、阿奇霉素和其他抗生素表现出高水平耐药性，但对头孢曲松敏感。SPC 高水平耐药性（MIC = 2048mg/L）是由于 中的小缺失导致核糖体蛋白 S5 中的两个氨基酸发生变化。