Kabwe Mwila, Brown Teagan, Speirs Lachlan, Ku Heng, Leach Michael, Chan Hiu Tat, Petrovski Steve, Lock Peter, Tucci Joseph
Department of Pharmacy and Biomedical Science, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
School of Rural Health, Monash University, Bendigo, VIC, Australia.
Front Microbiol. 2020 Feb 14;11:194. doi: 10.3389/fmicb.2020.00194. eCollection 2020.
The increase in global warming has favored growth of a range of opportunistic environmental bacteria and allowed some of these to become more pathogenic to humans. is one such organism. Surviving in moist conditions in temperate climates, these bacteria have been associated with a range of diseases in humans, and in systemic infections can cause mortality in up to 46% of cases. Their capacity to form biofilms, carry antibiotic resistance mechanisms, and survive disinfection, has meant that they are not easily treated with traditional methods. Bacteriophage offer a possible alternative approach for controlling their growth. This study is the first to report the isolation and characterization of bacteriophages lytic against clinical strains of which carry intrinsic antibiotic resistance genes. Functionally, these novel bacteriophages were shown to be capable of disrupting biofilms caused by clinical isolates of The potential exists for these to be tested in clinical and environmental settings.
全球变暖的加剧有利于多种机会性环境细菌的生长，并使其中一些细菌对人类更具致病性。 就是这样一种微生物。这些细菌在温带气候的潮湿环境中生存，与人类的一系列疾病有关，在全身感染中，高达46%的病例可能会导致死亡。它们形成生物膜、携带抗生素耐药机制以及在消毒后存活的能力，意味着它们难以用传统方法治疗。噬菌体为控制它们的生长提供了一种可能的替代方法。本研究首次报告了针对携带固有抗生素耐药基因的临床菌株具有裂解作用的噬菌体的分离和特性。从功能上看，这些新型噬菌体能够破坏由临床分离株引起的生物膜。它们有在临床和环境环境中进行测试的潜力。
