基因组特征分析一种新型噬菌体感染虹鳟鱼（Oncorhynchus mykiss）分离的嗜水气单胞菌。
Genomic characterization of a novel virulent phage infecting the Aeromonas hydrophila isolated from rainbow trout (Oncorhynchus mykiss).
机构信息
Laboratory of Fish Diseases, Department of Aquaculture, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Songfa Street No. 43, Daoli District, Harbin, 150070, China; Institute of Fisheries Science, Tibet Academy of Agricultural and Animal Husbandry Sciences, 130 Jinzhu West Road, Lhasa, 850002, Tibet, China.
Laboratory of Fish Diseases, Department of Aquaculture, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Songfa Street No. 43, Daoli District, Harbin, 150070, China.
出版信息
Virus Res. 2019 Nov;273:197764. doi: 10.1016/j.virusres.2019.197764. Epub 2019 Sep 21.
The virulent bacteriophage MJG that specifically infects Aeromonas hydrophila was isolated from a water sample from a river in Harbin, China. The genome of phage MJG was a double-stranded linear DNA with 45,057 bp, possessing 50.11% GC content. No virulence or resistance genes were found in the phage genome. Morphological observation, genomic characterization, and phylogenetic analysis indicated that MJG was closely related to phages belonging to the genus Sp6virus in the Podoviridae family. This phage is a novel member within Sp6virus that could infect and lyse A. hydrophila. This study could serve as a genomic reference of A. hydrophila phages and provide a potential agent for phage therapy.
从中国哈尔滨一条河流的水样中分离到一种专性感染嗜水气单胞菌的烈性噬菌体 MJG。噬菌体 MJG 的基因组是一个双链线性 DNA，长度为 45057bp，GC 含量为 50.11%。噬菌体基因组中未发现毒力或抗性基因。形态观察、基因组特征分析和系统发育分析表明，MJG 与 Podoviridae 科 Sp6virus 属的噬菌体密切相关。该噬菌体是 Sp6virus 属的一个新成员，能够感染和裂解嗜水气单胞菌。本研究可为嗜水气单胞菌噬菌体提供基因组参考，并为噬菌体治疗提供潜在的治疗剂。
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