miR-936抑制喉鳞状细胞癌的细胞增殖、侵袭及耐药性并靶向GPR78。
miR-936 Suppresses Cell Proliferation, Invasion, and Drug Resistance of Laryngeal Squamous Cell Carcinoma and Targets GPR78.
作者信息
Lin Xi-Jun, Liu Hui, Li Pei, Wang Hai-Feng, Yang An-Kui, Di Jin-Ming, Jiang Qi-Wei, Yang Yang, Huang Jia-Rong, Yuan Meng-Ling, Xing Zi-Hao, Wei Meng-Ning, Li Yao, Shi Zhi, Ye Jin
机构信息
Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Division of Pulmonary and Critical Care, Department of Internal Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
出版信息
Front Oncol. 2020 Feb 4;10:60. doi: 10.3389/fonc.2020.00060. eCollection 2020.
MicroRNAs (miRs) play important roles in tumor progression. miR-936 has been reported to suppress cell invasion and proliferation of glioma and non-small cell lung cancer. Nevertheless, the function of miR-936 in laryngeal squamous cell carcinoma (LSCC) remains undiscovered. Hence, our study was to investigate the role of miR-936 in LSCC. In our present research, we have testified that miR-936 was substantially downregulated in LSCC tissues compared with adjacent normal tissues. Furthermore, miR-936 could inhibit proliferation, migration and invasion, and improve the sensitivity to doxorubicin and cisplatin of LSCC cells. Additionally, luciferase reporter assays were performed to confirm that GPR78 was a novel target of miR-936, and the protein expression of GPR78 was obviously inhibited by miR-936 in LSCC cells. In summary, our study indicates that the miR-936/GPR78 axis could be both a diagnostic marker and a therapeutic target for LSCC.
微小RNA（miR）在肿瘤进展中发挥重要作用。据报道，miR-936可抑制胶质瘤和非小细胞肺癌的细胞侵袭与增殖。然而，miR-936在喉鳞状细胞癌（LSCC）中的功能仍未被发现。因此，我们的研究旨在探究miR-936在LSCC中的作用。在我们目前的研究中，我们证实与相邻正常组织相比，miR-936在LSCC组织中显著下调。此外，miR-936可抑制LSCC细胞的增殖、迁移和侵袭，并提高其对阿霉素和顺铂的敏感性。此外，进行荧光素酶报告基因实验以证实GPR78是miR-936的一个新靶点，并且在LSCC细胞中，miR-936可明显抑制GPR78的蛋白表达。总之，我们的研究表明miR-936/GPR78轴可能既是LSCC的诊断标志物，也是其治疗靶点。
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