Wang Baowei, Wang Zhiwen, Chen Tao, Zhao Xueming
Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China.
Front Bioeng Biotechnol. 2020 Feb 4;8:7. doi: 10.3389/fbioe.2020.00007. eCollection 2020.
Bioreactors of various forms have been widely used in environmental protection, healthcare, industrial biotechnology, and space exploration. Robust demand in the field stimulated the development of novel designs of bioreactor geometries and process control strategies and the evolution of the physical structure of the control system. After the introduction of digital computers to bioreactor process control, a hierarchical structure control system (HSCS) for bioreactors has become the dominant physical structure, having high efficiency and robustness. However, inherent drawbacks of the HSCS for bioreactors have produced a need for a more consolidated solution of the control system. With the fast progress in sensors, machinery, and information technology, the development of a flat organizational control system (FOCS) for bioreactors based on parallel distributed smart sensors and actuators may provide a more concise solution for process control in bioreactors. Here, we review the evolution of the physical structure of bioreactor control systems and discuss the properties of the novel FOCS for bioreactors and related smart sensors and actuators and their application circumstances, with the hope of further improving the efficiency, robustness, and economics of bioprocess control.
各种形式的生物反应器已广泛应用于环境保护、医疗保健、工业生物技术和太空探索领域。该领域的强劲需求推动了生物反应器几何形状的新型设计以及过程控制策略的发展，以及控制系统物理结构的演变。在将数字计算机引入生物反应器过程控制之后，用于生物反应器的分层结构控制系统（HSCS）已成为占主导地位的物理结构，具有高效性和鲁棒性。然而，生物反应器HSCS的固有缺点使得需要对控制系统有更综合的解决方案。随着传感器、机械和信息技术的快速发展，基于并行分布式智能传感器和执行器的生物反应器平面组织控制系统（FOCS）的开发可能为生物反应器中的过程控制提供更简洁的解决方案。在此，我们回顾生物反应器控制系统物理结构的演变，并讨论生物反应器新型FOCS以及相关智能传感器和执行器的特性及其应用情况，希望进一步提高生物过程控制的效率、鲁棒性和经济性。
