Sonbol Haitham, Brenaut Emilie, Nowak Emmanuel, Misery Laurent
Department of Dermatology, University Hospital, Brest, France.
Univ Brest, LIEN, Brest, France.
Front Med (Lausanne). 2020 Feb 7;7:35. doi: 10.3389/fmed.2020.00035. eCollection 2020.
Sensitive skin (SS) syndrome is defined by the occurrence of unpleasant sensations in response to stimuli that should normally not induce such sensations. It affects ~50% of women and 40% of men and can impact the quality of life. There is no consensus on therapeutic management. Phototherapy by light-emitting diodes (LEDs) is increasingly being used in dermatology for various inflammatory skin disorders with significant reduction in SS-10 and good tolerability. A Korean study suggested its efficacy in alleviating SS symptoms associated with other facial diseases. Our objective is to obtain preliminary data on the efficacy of phototherapy with LEDs for alleviating SS symptoms and increasing tolerance in subjects with SS that is not associated with other facial skin disorders. This monocentric pilot study included 30 subjects with SS who had a Sensitive Scale-10 score ≥40. The treatment consisted of red LED light exposure twice a week until significant reduction in SS-10 with a maximal treatment length of 8 weeks. The primary outcome was defined by a 60% decrease in the SS-10 score compared to the baseline. Thirty subjects were included; 83% were women, and the mean age was 28.9 years. Two participants were considered lost to follow-up. The cheeks (90%) and the nose (70%) were the most frequently involved parts of the face. Cold, heat, temperature variation, water and sun were the most frequent triggering factors. Twenty-eight subjects (93.3%, 95% CI 77.9 to 99.2%) achieved the primary outcome. Significant reduction in SS-10 was achieved in 77% of subjects in six sessions or fewer. The mean (SD) SS-10 scores were 54.7 (12.1) at inclusion, 14.4 (6.0) at the last session and 13.9 (7.5) 2 months after the last session, suggesting that the benefits persist for a few weeks. Two side effects were reported: both were allergic reactions to the nickel contained in the protective goggles. This pilot study had a small sample size and no control group. LEDs were effective in treating SS in all 28 subjects who completed the study in accordance with the protocol, and the benefits persisted for 2 months after the last LED therapy session.
敏感性皮肤（SS）综合征的定义是，在接触通常不应引发此类感觉的刺激时出现不适感。它影响约50%的女性和40%的男性，会对生活质量产生影响。在治疗管理方面尚无共识。发光二极管（LED）光疗在皮肤科越来越多地用于治疗各种炎症性皮肤病，能显著降低SS-10且耐受性良好。一项韩国研究表明其对缓解与其他面部疾病相关的SS症状有效。我们的目标是获取关于LED光疗缓解无其他面部皮肤疾病相关的SS症状及提高耐受性疗效的初步数据。这项单中心试点研究纳入了30名SS评分量表-10（SS-10）得分≥40的SS患者。治疗方案为每周进行两次红色LED光照，直至SS-10显著降低，最长治疗时长为8周。主要结局定义为与基线相比SS-10得分降低60%。共纳入30名受试者；83%为女性，平均年龄为28.9岁。两名参与者被视为失访。脸颊（90%）和鼻子（70%）是面部最常受累的部位。冷、热、温度变化、水和阳光是最常见的触发因素。28名受试者（93.3%，95%置信区间77.9%至99.2%）达到主要结局。77%的受试者在六次或更少次数的治疗后SS-10显著降低。纳入时SS-10的平均（标准差）得分为54.7（12.1），最后一次治疗时为14.4（6.0），最后一次治疗后2个月为13.9（7.5），表明益处可持续数周。报告了两例副作用：均为对防护眼镜中所含镍的过敏反应。这项试点研究样本量小且无对照组。按照方案完成研究的所有28名受试者中，LED光疗对治疗SS有效，且在最后一次LED治疗后益处持续了2个月。
