Lai Jianbo, Xu Tingting, Zhang Haorong, Xi Caixi, Zhou Hetong, Du Yanli, Jiang Jiajun, Wu Lingling, Zhang Peifen, Xu Yi, Hu Shaohua, Xu Dongrong
Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine.
The Key Laboratory of Mental Disorder's Management in Zhejiang Province.
Medicine (Baltimore). 2020 Feb;99(9):e19300. doi: 10.1097/MD.0000000000019300.
To characterize the fractional amplitude of low-frequency fluctuation (fALFF) in drug-naïve first-episode female patients with anorexia nervosa (AN) using resting-state functional magnetic resonance imaging (rs-fMRI).Whole brain rs-fMRI data were collected from 7 drug-naïve first-episode female patients with DSM-5 AN and 14 age-matched healthy female controls. fALFF values were calculated and compared between the two groups using a two-sample t test. Correlation analysis between the fALFF values in the entire brain and body mass index (BMI) was performed.Compared with the healthy controls, increased fALFF values were observed in the AN patients in their right hippocampus and left superior frontal gyrus, while decreased fALFF values were observed in their left rectus and left middle occipital gyrus. Moreover, low BMI was significantly associated with decreased fALFF in the left inferior frontal gyrus but increased fALFF in the left calcarine. In particular, the z-standardized fALFF (zfALFF) value of the left rectus was positive associated with BMI.Our findings suggest that spontaneous brain activity in the frontal region, hippocampus and rectus, characterized by fALFF values, was altered in drug-naïve, first-episode female patients with AN.
使用静息态功能磁共振成像（rs-fMRI）对未服用过药物的神经性厌食症（AN）首发女性患者的低频振幅分数（fALFF）进行特征分析。收集了7例符合DSM-5标准的未服用过药物的AN首发女性患者和14例年龄匹配的健康女性对照的全脑rs-fMRI数据。使用双样本t检验计算并比较两组的fALFF值。对全脑fALFF值与体重指数（BMI）进行相关性分析。与健康对照相比，AN患者右侧海马体和左侧额上回的fALFF值升高，而左侧直肌和左侧枕中回的fALFF值降低。此外，低BMI与左侧额下回fALFF降低但左侧距状裂fALFF升高显著相关。特别是，左侧直肌的z标准化fALFF（zfALFF）值与BMI呈正相关。我们的研究结果表明，以fALFF值为特征的额叶、海马体和直肌的自发脑活动在未服用过药物的AN首发女性患者中发生了改变。
