Wang Rong, Tang Zuohua, Liu Tingting, Sun Xinghuai, Wu Lingjie, Xiao Zebin
Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Shanghai Institute of Medical Imaging, Fudan University, Shanghai, 200031, China.
Neurol Sci. 2021 Jan;42(1):243-251. doi: 10.1007/s10072-020-04577-1. Epub 2020 Jul 6.
To explore the alterations of spontaneous neuronal activity and functional connectivity pattern using fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) in patients with primary angle-closure glaucoma (PACG) and fALFF relationship with the glaucoma clinical indices.
Forty-two PACG patients and 21 normal controls were enrolled in this study. Resting-state functional magnetic resonance imaging was firstly analyzed by fALFF and brain regions with altered fALFF between groups were selected as seeds for the further FC analysis. The relationships between fALFF/FC values of abnormal regions and ophthalmological measures, including mean deviation of visual field (MDVF) and retinal nerve fiber layer (RNFL) thickness, were also analyzed.
Compared with NC, PACG had significant lower fALFF values in the left cuneus, left middle temporal gyrus, right middle temporal gyrus, and right precentral gyrus, while higher fALFF values in the bilateral superior frontal gyrus (P < 0.05 after correction). Furthermore, PACG showed increased FC between left cuneus and bilateral superior frontal gyrus/bilateral posterior cingulate gyrus; between left middle temporal gyrus and bilateral superior frontal gyrus; and between right middle temporal gyrus and bilateral insular (P < 0.05 after correction). In addition, in the PACG group, the mean fALFF values of the left cuneus were positively correlated with MDVF (R = 0.419, P = 0.005) and RNFL thickness (R = 0.322, P = 0.038). Meanwhile, the mean fALFF values of bilateral superior frontal gyrus were negatively correlated with MDVF (R = - 0.454, P = 0.003) and RNFL thickness (R = - 0.556, P < 0.001).
PACG exhibited abnormal spontaneous neural activity and connectivity in several brain regions mainly associated with visual and visual-related functions. In addition, the fALFF values of the left cuneus and bilateral superior frontal gyrus may be complementary biomarkers for assessing the disease severity.
采用低频振幅分数（fALFF）和功能连接（FC）探讨原发性闭角型青光眼（PACG）患者自发神经元活动和功能连接模式的改变，以及fALFF与青光眼临床指标的关系。
本研究纳入42例PACG患者和21例正常对照。首先通过fALFF分析静息态功能磁共振成像，并选择组间fALFF改变的脑区作为种子进行进一步的FC分析。还分析了异常区域的fALFF/FC值与眼科指标之间的关系，包括视野平均偏差（MDVF）和视网膜神经纤维层（RNFL）厚度。
与正常对照相比，PACG患者左侧楔叶、左侧颞中回、右侧颞中回和右侧中央前回的fALFF值显著降低，而双侧额上回的fALFF值较高（校正后P < 0.05）。此外，PACG患者左侧楔叶与双侧额上回/双侧后扣带回之间；左侧颞中回与双侧额上回之间；以及右侧颞中回与双侧岛叶之间的FC增加（校正后P < 0.05）。此外，在PACG组中，左侧楔叶的平均fALFF值与MDVF（R = 0.419，P = 0.005）和RNFL厚度（R = 0.322，P = 0.038）呈正相关。同时，双侧额上回的平均fALFF值与MDVF（R = -0.454，P = 0.003）和RNFL厚度（R = -0.556，P < 0.001）呈负相关。
PACG在几个主要与视觉和视觉相关功能有关的脑区表现出自发神经活动和连接异常。此外，左侧楔叶和双侧额上回的fALFF值可能是评估疾病严重程度的补充生物标志物。
