撒哈拉沙尘对急性冠状动脉综合征发病率的影响。

Impact of Saharan dust on the incidence of acute coronary syndrome.

作者信息

Domínguez-Rodríguez Alberto, Rodríguez Sergio, Baez-Ferrer Néstor, Avanzas Pablo, Abreu-González Pedro, Silva Jacobo, Morís César, Hernández-Vaquero Daniel

机构信息

Servicio de Cardiología, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain; Facultad de Ciencias de la Salud, Universidad Europea de Canarias, La Orotava, Santa Cruz de Tenerife, Spain; Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (CIBERCV), Madrid, Spain.

Estación Experimental de Zonas Áridas (EEZA), Consejo Superior de Investigaciones Científicas (CSIC), Almería, Spain; Instituto de Productos Naturales y Agrobiología (IPNA), Consejo Superior de Investigaciones Científicas (CSIC), San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.

出版信息

Rev Esp Cardiol (Engl Ed). 2021 Apr;74(4):321-328. doi: 10.1016/j.rec.2020.02.003. Epub 2020 Mar 1.

DOI:10.1016/j.rec.2020.02.003

PMID:32127342

Abstract

INTRODUCTION AND OBJECTIVES

Asian desert dust has recently been recognized as a trigger for acute myocardial infarction. The inflow of dust from the Sahara into Spain impairs air quality due to an increase in particulate matter concentrations in the ambient air. The aim of the present study was to elucidate whether Saharan dust events are associated with the incidence of acute coronary syndrome (ACS) in patients living near North Africa, the major global dust source.

METHODS

We prospectively collected data on hospitalizations due to ACS in 2416 consecutive patients from a tertiary care hospital (Canary Islands, Spain) from December 2012 to December 2017. Concentrations of particulate matter with an aerodynamic diameter 10 microns or smaller (PM) and reactive gases were measured in the European Air Quality Network implemented in the Canary Islands. We applied the time-stratified case crossover design using conditional Poisson regression models to estimate the impact of PM Saharan dust events on the incidence of ACS.

RESULTS

The occurrence of Saharan dust events observed 0 to 5 days before the onset of ACS was not significantly associated with the incidence of ACS. Incidence rate ratios (IRR) of PM levels 1, 2, 3, 4 and 5 days before ACS onset (for changes in 10μg/m) were 1.27 (95%CI, 0.87-1.85), 0.92 (95%CI, 0.84-1.01), 0.74 (95%CI, 0.45-1.22), 0.98 (95%CI, 0.87-1.11), and 0.95 (95%CI, 0.84-1.06), respectively.

CONCLUSIONS

Exposure to Saharan desert dust is unlikely to be associated with the incidence of ACS.

摘要

引言与目的

亚洲沙漠尘土最近被认为是急性心肌梗死的一个触发因素。由于撒哈拉沙漠的沙尘流入西班牙，导致环境空气中颗粒物浓度增加，从而损害了空气质量。本研究的目的是阐明撒哈拉沙尘事件是否与生活在北非（全球主要沙尘源）附近的患者急性冠状动脉综合征（ACS）的发病率相关。

方法

我们前瞻性地收集了2012年12月至2017年12月期间，来自一家三级护理医院（西班牙加那利群岛）的2416例连续ACS住院患者的数据。在加那利群岛实施的欧洲空气质量网络中，测量了空气动力学直径为10微米或更小的颗粒物（PM）和活性气体的浓度。我们采用时间分层病例交叉设计，使用条件泊松回归模型来估计PM撒哈拉沙尘事件对ACS发病率的影响。

结果

在ACS发病前0至5天观察到的撒哈拉沙尘事件的发生与ACS的发病率没有显著关联。ACS发病前1、2、3、4和5天的PM水平（每变化10μg/m）的发病率比值（IRR）分别为1.27（95%CI，0.87 - 1.85）、0.92（95%CI，0.84 - 1.01）、0.74（95%CI，0.45 - 1.22）、0.98（95%CI，0.87 - 1.11）和0.95（95%CI，0.84 - 1.06）。