Sah Shyam Kishor, Agrahari Gaurav, Kim Tae-Yoon
1Department of Reconstructive Sciences, Center for Regenerative Medicine and Skeletal Development, University of Connecticut Health Center, Farmington, CT 06032 USA.
2Laboratory of Dermato-immunology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 06591 Republic of Korea.
Cell Biosci. 2020 Feb 27;10:22. doi: 10.1186/s13578-020-00386-3. eCollection 2020.
Mesenchymal stem cells (MSCs) have been extensively studied and implicated for the cell-based therapy in several diseases due to theirs immunomodulatory properties. Embryonic stem cells and induced-pluripotent stem cells have either ethical issues or concerns regarding the formation of teratomas, introduction of mutations into genome during prolonged culture, respectively which limit their uses in clinical settings. On the other hand, MSCs also encounter certain limitation of circumscribed survival and reduced immunomodulatory potential during transplantation. Plethora of research is undergoing to improve the efficacy of MSCs during therapy. Several compounds and novel techniques have been employed to increase the therapeutic potency of MSCs. MSCs secreted superoxide dismutase 3 (SOD3) may be the mechanism for exhibiting direct antioxidant activities by MSCs. SOD3 is a well known antioxidant enzyme and recently known to possess immunomodulatory properties. Along with superoxide scavenging property, SOD3 also displays anti-angiogenic, anti-chemotactic and anti-inflammatory functions in both enzymatic and non-enzymatic manners. In this review, we summarize the emerging role of SOD3 secreted from MSCs and SOD3's effects during cell-based therapy.
间充质干细胞（MSCs）由于其免疫调节特性，已被广泛研究并用于多种疾病的细胞治疗。胚胎干细胞和诱导多能干细胞分别存在伦理问题或长期培养过程中基因组发生突变形成畸胎瘤的问题，这限制了它们在临床中的应用。另一方面，MSCs在移植过程中也存在存活受限和免疫调节潜能降低等问题。目前正在进行大量研究以提高MSCs在治疗中的疗效。已采用多种化合物和新技术来提高MSCs的治疗效力。MSCs分泌的超氧化物歧化酶3（SOD3）可能是MSCs发挥直接抗氧化活性的机制。SOD3是一种众所周知的抗氧化酶，最近发现它还具有免疫调节特性。除了超氧化物清除特性外，SOD3还以酶促和非酶促方式发挥抗血管生成、抗趋化和抗炎功能。在本综述中，我们总结了MSCs分泌的SOD3的新作用及其在细胞治疗中的作用。
