Department of Veterinary Clinical Sciences, Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
PLoS One. 2024 May 14;19(5):e0303136. doi: 10.1371/journal.pone.0303136. eCollection 2024.
Superoxide dismutase (SOD) is an antioxidant enzyme that protects the body from free radicals. It has both antioxidant and immunomodulatory properties, inducing macrophage polarization from M1 to M2. Macrophages, key mediators of the innate immune response, are divided into the M1 (pro-inflammatory) and M2 (anti-inflammatory) subtypes. In this study, we aimed to assess the antioxidant and neuroprotective effects of SOD on nerve cells and its immunomodulatory effects on macrophages. We observed that SOD inhibited the accumulation of reactive oxygen species and enhanced the viability of H2O2-treated nerve cells. Furthermore, SOD reduced the degree of necrosis in nerve cells treated with the conditioned medium from macrophages, which induced inflammation. In addition, SOD promoted the M1 to M2 transition of macrophages. Our findings suggest that SOD protects nerve cells and regulates immune responses.
超氧化物歧化酶（SOD）是一种抗氧化酶，可保护人体免受自由基侵害。它具有抗氧化和免疫调节特性，可诱导巨噬细胞从 M1 向 M2 极化。巨噬细胞是先天免疫反应的关键介质，分为 M1（促炎）和 M2（抗炎）两种亚型。在这项研究中，我们旨在评估 SOD 对神经细胞的抗氧化和神经保护作用及其对巨噬细胞的免疫调节作用。我们观察到 SOD 抑制了活性氧的积累并增强了 H2O2 处理的神经细胞的活力。此外，SOD 降低了由诱导炎症的巨噬细胞条件培养基处理的神经细胞的坏死程度。此外，SOD 促进了巨噬细胞从 M1 向 M2 的转化。我们的研究结果表明，SOD 可保护神经细胞并调节免疫反应。
