Department of Infectious Disease, The First Affiliated Hospital, University of South China, Hengyang 421001, China.
Department of Pharmacy, The First Affiliated Hospital, University of South China, Hengyang 421001, China.
Biomed Res Int. 2021 Feb 5;2021:9850928. doi: 10.1155/2021/9850928. eCollection 2021.
Nasopharyngeal carcinoma (NPC) is a kind of malignancy generated from the nasopharyngeal epithelium. Recently, long noncoding RNA (lncRNA) has been shown to be involved in the regulation of many signaling pathways and is closely associated with carcinogenesis and tumor progression. However, the precise role of lncRNA Opa-interacting protein 5 antisense RNA 1 (OIP5-AS1) in NPC is not well understood. Here, we find that OIP5-AS1 is overexpressed in NPC patient specimens and NPC cell lines. Further investigations reveal that knockdown of OIP5-AS1 significantly inhibits the proliferation, migration, and invasion and accelerates the apoptosis of NPC cells Consistent with these findings, NPC progression is significantly slowed in mice when OIP5-AS1 is knocked down. Interestingly, there is a functional link between OIP5-AS1 and microRNA-203 (miR-203), a tumor suppressor, in NPC cells. In conclusion, our data demonstrate that OIP5-AS1 plays an important role in the development and progression of NPC by targeting miR-203 and therefore provide a promising target for the treatment of NPC.
鼻咽癌（NPC）是一种来源于鼻咽部上皮的恶性肿瘤。最近，长链非编码 RNA（lncRNA）被证明参与了许多信号通路的调节，与癌发生和肿瘤进展密切相关。然而，lncRNA Opa 相互作用蛋白 5 反义 RNA 1（OIP5-AS1）在 NPC 中的精确作用尚不清楚。在这里，我们发现 OIP5-AS1 在 NPC 患者标本和 NPC 细胞系中过表达。进一步的研究表明，敲低 OIP5-AS1 显著抑制 NPC 细胞的增殖、迁移和侵袭，并加速其凋亡。与此一致的是，当敲低 OIP5-AS1 时，NPC 在小鼠中的进展明显减慢。有趣的是，在 NPC 细胞中，OIP5-AS1 与肿瘤抑制因子 microRNA-203（miR-203）之间存在功能联系。总之，我们的数据表明，OIP5-AS1 通过靶向 miR-203 在 NPC 的发生和发展中发挥重要作用，因此为 NPC 的治疗提供了一个有前途的靶点。
