Cai Zhilong, Rui Shuoyu, Huang Nanqu, Feng Fei, Luo Yong
Department of Neurology, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.
National Drug Clinical Trial Institution, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.
Front Nutr. 2025 Jun 2;12:1595813. doi: 10.3389/fnut.2025.1595813. eCollection 2025.
Vitamin D, an essential neuroendocrine regulator, exhibits a significant dose-dependent association with various sleep disorders according to epidemiological evidence, and plays a multifaceted and critical role in sleep regulation. This review summarizes the molecular mechanisms, clinical applications, and future directions of vitamin D in sleep regulation. Vitamin D may influence sleep through multiple molecular pathways, including modulation of neurotransmitter systems, maintenance of circadian rhythms, and neuroimmune regulation. Clinical trials have demonstrated that vitamin D supplementation significantly improves sleep quality, particularly in special populations such as the elderly and pregnant women. However, challenges persist in optimizing individualized treatment regimens, developing novel drug delivery systems, and evaluating long-term efficacy. The integration of multi-omics analyses and artificial intelligence offers innovative solutions to these challenges. Future research should focus on elucidating the precise molecular mechanisms of vitamin D in sleep regulation, refining personalized therapeutic strategies, and advancing innovative delivery systems to enhance the prevention and treatment of sleep disorders.
维生素D是一种重要的神经内分泌调节剂，流行病学证据表明，它与各种睡眠障碍存在显著的剂量依赖性关联，并在睡眠调节中发挥多方面的关键作用。本综述总结了维生素D在睡眠调节中的分子机制、临床应用及未来方向。维生素D可能通过多种分子途径影响睡眠，包括调节神经递质系统、维持昼夜节律和神经免疫调节。临床试验表明，补充维生素D可显著改善睡眠质量，尤其是在老年人和孕妇等特殊人群中。然而，在优化个体化治疗方案、开发新型药物递送系统以及评估长期疗效方面仍存在挑战。多组学分析与人工智能的整合为这些挑战提供了创新解决方案。未来的研究应聚焦于阐明维生素D在睡眠调节中的精确分子机制、完善个性化治疗策略以及推进创新递送系统，以加强睡眠障碍的预防和治疗。
