Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, 330006, Nanchang, Jiangxi, China.
Division of Prevention and Community Health, National Center for Cardiovascular Disease, Fuwai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No.167 North Lishi Road, Xicheng District, Beijing 100037, China.
Sleep Med. 2018 Jul;47:36-43. doi: 10.1016/j.sleep.2017.11.1147. Epub 2018 Jan 4.
This study aimed to assess the relationship between sleep duration on work or nonworkdays and myocardial infarction (MI) and stroke in Southern China.
A cross-sectional survey was conducted among 15,364 participants of age ≥15 years in Southern China from November 2013 to August 2014. Data on self-reported duration of sleep on workdays or nonworkdays as well as history of MI and stroke were collected in the questionnaire. The subjects were examined for weight, height, waist circumference, and blood pressure. Multivariate logistic regression analyses were performed to evaluate the association of sleep duration with MI and stroke.
Overall, compared with a sleep duration of 6-8 h, individuals who slept <6 h on workdays and nonworkdays were associated with increased risk for MI (odds ratio [OR] = 3.17, 2.04). Furthermore, individuals who slept >8 h on workdays and nonworkdays were associated with an increased risk for stroke (OR = 1.86, 1.54). Although this association persisted in men and subjects aged <65 years, we also observed that long sleep duration on workdays was associated with MI, especially among women, and short sleep duration on nonworkdays was associated with stroke among those aged 65 years or older. Participants with abnormal sleep duration and hypertension had higher risk of MI and stroke. Sleep debt was independently associated with MI risk, but not stroke (OR = 1.40; 95% confidence interval [CI]: 1.06-1.86), specifically among men aged <65 years.
Compared with a sleep duration of 6-8 h, both short and long sleep duration were associated with the prevalence of MI and stroke and these associations were more pronounced among hypertensive persons, and tended to vary by age and sex. Moreover, sleep debt was linked to greater MI risk among men aged <65 years. These findings suggest that we should develop a healthy biological clock.
本研究旨在评估中国南方地区工作日和非工作日睡眠时间与心肌梗死（MI）和中风的关系。
2013 年 11 月至 2014 年 8 月期间，在中国南方地区对 15364 名年龄≥15 岁的参与者进行了一项横断面调查。调查问卷中收集了自我报告的工作日和非工作日睡眠时间以及 MI 和中风病史的数据。对受试者进行体重、身高、腰围和血压检查。采用多变量 logistic 回归分析评估睡眠时间与 MI 和中风的关系。
总体而言，与 6-8 小时睡眠时间相比，工作日和非工作日睡眠时间<6 小时的个体患 MI 的风险增加（比值比 [OR] = 3.17，2.04）。此外，工作日和非工作日睡眠时间>8 小时的个体患中风的风险增加（OR = 1.86，1.54）。尽管这种关联在男性和<65 岁的受试者中仍然存在，但我们也发现工作日睡眠时间过长与 MI 有关，尤其是女性，而 65 岁或以上人群的非工作日睡眠时间过短与中风有关。睡眠时间异常和高血压的参与者患 MI 和中风的风险更高。睡眠债与 MI 风险独立相关，但与中风无关（OR = 1.40；95%置信区间 [CI]：1.06-1.86），尤其是<65 岁的男性。
与 6-8 小时睡眠时间相比，短时间和长时间睡眠都与 MI 和中风的患病率有关，这些关联在高血压患者中更为明显，且倾向于因年龄和性别而异。此外，睡眠债与<65 岁男性的 MI 风险增加有关。这些发现表明，我们应该养成健康的生物钟。
