Laboratory of Clinical Cytology and Semen Analysis, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, PR, Brazil.
Division of Epidemiology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, PR, Brazil.
Nat Rev Urol. 2019 Apr;16(4):211-230. doi: 10.1038/s41585-019-0149-7.
Zika virus (ZIKV) is a re-emerging mosquito-transmitted flavivirus associated with congenital abnormalities in newborns and with Guillain-Barré syndrome in adults. The virus can also be sexually transmitted and can persist in the male genital tract. Studies evaluating the kinetics of ZIKV in seminal shedding of men who have been infected, as well as in animal and cellular models of infection, have shown that, in addition to the testis and epididymis, the prostate and seminal vesicles could also be involved in persistent ZIKV infection. Additionally, some studies have reported that men infected with ZIKV can present with genitourinary symptoms such as haematospermia, prostatitis, painful ejaculation, penile discharge, and oligospermia; however, little is known about the effect of ZIKV on fertility. Understanding the mechanisms that underlie persistent ZIKV infections in men is crucial to developing guidelines, effective vaccines, and therapies.
Zika 病毒（ZIKV）是一种重新出现的蚊媒传播的黄病毒，与新生儿先天性异常和成人吉兰-巴雷综合征有关。该病毒也可以通过性传播，并能在男性生殖道内持续存在。评估已感染男性的精液脱落中 ZIKV 动力学，以及动物和细胞感染模型的研究表明，除了睾丸和附睾外，前列腺和精囊也可能参与持续的 ZIKV 感染。此外，一些研究报告称，感染 ZIKV 的男性可能出现血精症、前列腺炎、射精痛、阴茎分泌物和少精子症等泌尿道症状；然而，对于 ZIKV 对生育能力的影响知之甚少。了解导致男性持续 ZIKV 感染的机制对于制定指南、有效疫苗和治疗方法至关重要。
