女性生殖道病毒组：了解病毒在妇科健康和疾病中的动态作用。
The female reproductive tract virome: understanding the dynamic role of viruses in gynecological health and disease.
机构信息
Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, USA.
Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, USA; Department of Internal Medicine, Division of Infectious Diseases, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, USA.
出版信息
Curr Opin Virol. 2022 Feb;52:15-23. doi: 10.1016/j.coviro.2021.10.010. Epub 2021 Nov 17.
Abstract
The human body is inhabited by a large and complex network of commensal and predatory eukaryotic viruses and bacteriophages collectively termed the virome. Despite being the most abundant and genetically diverse biological entities on the planet, the impact of viruses on human health especially within the female reproductive tract (FRT) remains understudied. To better appreciate current knowledge regarding the dynamic role of viruses in FRT health and disease, in this review we highlight the known constituents of the FRT virome, transkingdom interactions within the FRT and their influence on gynecological disease. A better understanding of the FRT virome may pave the way toward improved outcomes in gynecological, reproductive, and neonatal health.
摘要
人体中栖息着大量复杂的共生和捕食性真核病毒和噬菌体网络，统称为病毒组。尽管病毒是地球上最丰富和最多样化的生物实体，但它们对人类健康的影响，尤其是在女性生殖道 (FRT) 中的影响，仍研究不足。为了更好地了解病毒在 FRT 健康和疾病中的动态作用，本综述强调了 FRT 病毒组的已知成分、FRT 中的跨物种相互作用及其对妇科疾病的影响。更好地了解 FRT 病毒组可能为改善妇科、生殖和新生儿健康的结果铺平道路。
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2
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Nat Rev Microbiol. 2021 Aug;19(8):514-527. doi: 10.1038/s41579-021-00536-5. Epub 2021 Mar 30.
3
Comparison of viromes in vaginal secretion from pregnant women with and without vaginitis.比较孕妇阴道炎患者和非阴道炎患者阴道分泌物中的病毒组。
Virol J. 2021 Jan 6;18(1):11. doi: 10.1186/s12985-020-01482-z.
4
Comparative analysis of Bacterial Vaginosis microbiota among pregnant and non-pregnant females and isolation of phages against Enterococcus faecalis, Enterococcus faecium, and Shigella flexneri strains.比较分析孕妇和非孕妇阴道微生物菌群的差异，并分离针对粪肠球菌、屎肠球菌和福氏志贺菌的噬菌体。
Microb Pathog. 2020 Dec;149:104588. doi: 10.1016/j.micpath.2020.104588. Epub 2020 Oct 22.
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