Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, USA.
Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, USA; Department of Internal Medicine, Division of Infectious Diseases, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, USA.
Curr Opin Virol. 2022 Feb;52:15-23. doi: 10.1016/j.coviro.2021.10.010. Epub 2021 Nov 17.
The human body is inhabited by a large and complex network of commensal and predatory eukaryotic viruses and bacteriophages collectively termed the virome. Despite being the most abundant and genetically diverse biological entities on the planet, the impact of viruses on human health especially within the female reproductive tract (FRT) remains understudied. To better appreciate current knowledge regarding the dynamic role of viruses in FRT health and disease, in this review we highlight the known constituents of the FRT virome, transkingdom interactions within the FRT and their influence on gynecological disease. A better understanding of the FRT virome may pave the way toward improved outcomes in gynecological, reproductive, and neonatal health.
人体中栖息着大量复杂的共生和捕食性真核病毒和噬菌体网络，统称为病毒组。尽管病毒是地球上最丰富和最多样化的生物实体，但它们对人类健康的影响，尤其是在女性生殖道 (FRT) 中的影响，仍研究不足。为了更好地了解病毒在 FRT 健康和疾病中的动态作用，本综述强调了 FRT 病毒组的已知成分、FRT 中的跨物种相互作用及其对妇科疾病的影响。更好地了解 FRT 病毒组可能为改善妇科、生殖和新生儿健康的结果铺平道路。
