通过胆汁酸修饰调节微生物组对宿主适应性免疫的作用。
Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification.
机构信息
Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands.
Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands.
出版信息
Cell Metab. 2020 Mar 3;31(3):445-447. doi: 10.1016/j.cmet.2020.02.006.
The microbiome is well known to influence the immune response of the host. Song et al. now show that the microbiome modulates adaptive immunity in mice through formation of bile acid species acting on RORγ regulatory T cells via the Vitamin D Receptor, thereby lowering the vulnerability for chemically induced colitis.
微生物组众所周知会影响宿主的免疫反应。Song 等人现在表明，微生物组通过形成作用于 RORγ 调节性 T 细胞的胆汁酸种类来调节小鼠的适应性免疫，从而降低化学诱导结肠炎的易感性。
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