Oldoini Giacomo, Frabattista Giulia Ricci, Saragoni Maria, Cosola Saverio, Giammarinaro Ernica, Genovesi Anna Maria, Marconcini Simone
Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy.
Private clinician, Liguria, Italy.
Eur J Case Rep Intern Med. 2020 Jan 14;7(2):001406. doi: 10.12890/2020_001406. eCollection 2020.
Chemotherapy usually causes complications affecting several tissues such as oral mucosa. In this case report, a soft palate oral ulcer caused by chemotherapy was treated by ozone gas. This kind of treatment is known for its antimicrobial, regenerative and analgesic proprieties. The results show a complete resolution of the lesion within 2 weeks of treatment. Ozone therapy demonstrates greater effectiveness with respect to this kind of oral lesion compared to traditional therapy. Considering this evidence, ozone therapy should be considered as a useful tool for the adjuvant therapy of oral complications in oncologic patients.
Intensive chemotherapy can have side effects, particularly affecting tissue with higher turnover. Therefore, there is a clinical need to prevent or to treat such complications.Ozone therapy could improve oral mucosa healing and have anti-inflammatory, antioxidant and antibacterial effects to prevent suprainfections. To date, there are no reported cases of oral ulcers in oncologic patients being completely resolved using ozone in the literature.Medical and dental doctors should collaborate with regards to complex patients to prevent such types of complications, discovering these clinical cases that are unknown in the literature and treating patients in a more comprehensive way.
化疗通常会引发影响多个组织(如口腔黏膜)的并发症。在本病例报告中,化疗引起的软腭口腔溃疡采用臭氧气体进行治疗。这种治疗方法以其抗菌、再生和止痛特性而闻名。结果显示,治疗2周内病变完全消退。与传统疗法相比,臭氧疗法对这类口腔病变显示出更高的疗效。鉴于此证据,臭氧疗法应被视为肿瘤患者口腔并发症辅助治疗的有用工具。
强化化疗可能会产生副作用,尤其会影响更新率较高的组织。因此,临床上需要预防或治疗此类并发症。臭氧疗法可以促进口腔黏膜愈合,并具有抗炎、抗氧化和抗菌作用以预防继发感染。迄今为止,文献中尚无肿瘤患者口腔溃疡使用臭氧完全治愈的报道。对于复杂患者,医生和牙医应协作预防此类并发症,发现文献中未知的临床病例,并以更全面的方式治疗患者。