Vekic Berislav, Dragojevic-Simic Viktorija, Jakovljevic Mihajlo, Kalezic Marko, Zagorac Zagor, Dragovic Sasa, Zivic Rastko, Pilipovic Filip, Simic Radoje, Jovanovic Dejan, Milovanovic Jovana, Rancic Nemanja
Department of Surgery, Clinical Centre Dr. Dragisa Misovic, Belgrade, Serbia.
Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Front Public Health. 2020 Feb 18;8:29. doi: 10.3389/fpubh.2020.00029. eCollection 2020.
Colorectal cancer (CRC) is one of the most commonly diagnosed malignant neoplasms. The aim of the study was to evaluate and correlate most important epidemiological and economic indicators of CRC in 11 selected Balkan countries. The number of new CRC cases was 56,960, and the highest 5-year CRC prevalence was in Slovenia, Croatia, and Greece. Age-standardized CRC incidence rates were highest in Slovenia, Serbia, and Croatia, and age-standardized mortality rates were highest in Croatia, Serbia, and Bulgaria. Current Health Expenditure as % of Gross Domestic Product was the highest in Bosnia and Herzegovina and Serbia. The GDP per capita levels have shown positive correlation with the CRC incidence rate and prevalence. Absolute numbers of new and death-related CRC cases and 5-year prevalence in absolute numbers have shown strong positive correlation with GDP in million current US$. It has been shown that various economic indicators can be linked to the rate of incidence and prevalence of the CRC patients in the selected Balkan countries. Therefore, economic factors can influence the epidemiology of CRC, and heavy CRC burden in the Balkan region may be one of the indexes of the economic development.
结直肠癌（CRC）是最常被诊断出的恶性肿瘤之一。该研究的目的是评估11个选定巴尔干国家中结直肠癌最重要的流行病学和经济指标并进行关联分析。新结直肠癌病例数为56,960例，5年结直肠癌患病率最高的是斯洛文尼亚、克罗地亚和希腊。年龄标准化结直肠癌发病率在斯洛文尼亚、塞尔维亚和克罗地亚最高，年龄标准化死亡率在克罗地亚、塞尔维亚和保加利亚最高。卫生支出占国内生产总值的百分比在波斯尼亚和黑塞哥维那以及塞尔维亚最高。人均国内生产总值水平与结直肠癌发病率和患病率呈正相关。新发病例和与死亡相关的结直肠癌病例的绝对数以及5年患病率的绝对数与以百万当前美元计的国内生产总值呈强正相关。研究表明，在选定的巴尔干国家，各种经济指标可与结直肠癌患者的发病率和患病率相关联。因此，经济因素可影响结直肠癌的流行病学，巴尔干地区沉重的结直肠癌负担可能是经济发展的指标之一。
