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从非靶向液相色谱-高分辨率质谱分析中得出定量结论的策略。

Strategies for Drawing Quantitative Conclusions from Nontargeted Liquid Chromatography-High-Resolution Mass Spectrometry Analysis.

机构信息

Institute of Chemistry, University of Tartu, Ravila 14a, Tartu 50411, Estonia.

Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE-106 91 Stockholm, Sweden.

出版信息

Anal Chem. 2020 Apr 7;92(7):4691-4699. doi: 10.1021/acs.analchem.9b03481. Epub 2020 Mar 23.

DOI:10.1021/acs.analchem.9b03481
PMID:32134258
Abstract

This Feature aims at giving an overview of different possibilities for quantitatively comparing the results obtained from LC-HRMS-based nontargeted analysis. More specifically, quantification via structurally similar internal standards, different isotope labeling strategies, radiolabeling, and predicted ionization efficiencies are reviewed.

摘要

本专题旨在概述基于 LC-HRMS 的非靶向分析中定量比较结果的不同可能性。更具体地说，综述了通过结构相似的内标物、不同的同位素标记策略、放射性标记和预测的电离效率进行定量的方法。

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