Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo.
Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima.
J Glaucoma. 2020 Jun;29(6):479-484. doi: 10.1097/IJG.0000000000001486.
Corvis ST Tonometry and Ocular Response Analyzer (ORA) measurements were conducted in primary open-angle glaucoma and normative subjects. Many parameters were significantly correlated, however, the strengths were weak to moderate.
Reichert ORA parameters are derived from pressure information following the application of air-jet, whereas detailed structural observation can be made using the Corneal Visualization Scheimpflug Technology instrument (CST). The purpose of the study was to investigate the association between CST measurements and ORA measured corneal hysteresis (CH).
Measurements of CST, ORA, axial length, average corneal curvature, central corneal thickness (CCT) and intraocular pressure with Goldmann applanation tonometry were carried out in 104 eyes of 104 patients with primary open-angle glaucoma and 35 eyes from normative subjects. The association between CST and ORA parameters was assessed using linear regression analysis, with model selection based on the second order bias corrected Akaike Information Criterion index.
Deformation amplitude ratio (corneal softness, R=-0.51), SP A1 (corneal stiffness, R=0.41), and Inverse Radius (integrated area under the curve of the inverse concave radius, R=-0.44) were significantly correlated with CH (P <0.05). The optimal model to explain CH using CST measurements was given by: CH=-76.3+4.6×A1 time (applanation time in the corneal inward movement)+1.9×A2 time (second applanation time in the corneal outward movement) + 3.1 × highest concavity deformation amplitude (magnitude of movement of the corneal apex from before deformation to its highest concavity) + 0.016×CCT (R=0.67; P<0.001).
CST parameters are significant, but weakly or moderately, related to ORA measured CH.
在原发性开角型青光眼和正常人群中进行了 Corvis ST 眼压计和眼反应分析仪（ORA）测量。许多参数呈显著相关，但相关性强弱为弱至中度。
Reichert ORA 参数是在空气喷射后应用压力信息得出的，而 Corneal Visualization Scheimpflug Technology 仪器（CST）可进行详细的结构观察。本研究旨在探讨 CST 测量值与 ORA 测量的角膜滞后（CH）之间的关系。
对 104 例原发性开角型青光眼患者的 104 只眼和 35 只正常眼进行了 CST、ORA、眼轴长度、平均角膜曲率、中央角膜厚度（CCT）和 Goldmann 压平眼压测量。采用线性回归分析评估 CST 和 ORA 参数之间的关系，模型选择基于二阶偏置校正 Akaike 信息准则指数。
变形幅度比（角膜柔软度，R=-0.51）、SP A1（角膜硬度，R=0.41）和逆半径（反向凹半径曲线下面积的积分，R=-0.44）与 CH 显著相关（P<0.05）。使用 CST 测量值解释 CH 的最佳模型为：CH=-76.3+4.6×A1 时间（角膜向内移动的压平时间）+1.9×A2 时间（角膜向外移动的第二次压平时间）+3.1×最高凹陷变形幅度（角膜顶点从变形前到最高点的运动幅度）+0.016×CCT（R=0.67；P<0.001）。
CST 参数与 ORA 测量的 CH 显著相关，但相关性强弱为弱至中度。
